Indexing signal detection module

Patent metadata

Field	Value
Publication number	US-10120136-B2
Application number	US-201615287358-A
Country	US
Kind code	B2
Filing date	Oct 6, 2016
Priority date	Mar 14, 2013
Publication date	Nov 6, 2018
Grant date	Nov 6, 2018

Abstract

An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

First claim

The invention claimed is:

1. An apparatus for transmitting an optical signal emission from the contents of each of a plurality of receptacles, said apparatus comprising:
a processing module configured to hold the plurality of receptacles;
a plurality of signal transmission conduits, each signal transmission conduit comprising an optical fiber coupled to the processing module to transmit an optical signal emitted by the contents of an associated one of the plurality of receptacles between a first end and a second end thereof, wherein each of the plurality of signal transmission conduits transmits both an excitation and an emission signal; and
a conduit reformatter constructed and arranged to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the plurality of receptacles held within the processing module, such that the first end of each signal transmission conduit is positioned to receive an emission signal emitted by the contents of the associated receptacle, and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

2. The apparatus of claim 1 , wherein the first spatial arrangement is rectangular and comprises two or more rows, each row including two or more of the first ends of the signal transmission conduits.

3. The apparatus of claim 1 , wherein the second spatial arrangement comprises one or more circles, whereby the second ends of a plurality of signal transmission conduits are positioned about the circumference of a circle.

4. The apparatus of claim 1 , wherein the second spatial arrangement comprises one or more bundles whereby the second ends of a plurality of signal transmission conduits are collected in a bundle wherein the second ends of the transmission fibers in the bundle are in close proximity to each other.

5. The apparatus of claim 1 , wherein said conduit reformatter comprises a reformatter frame comprising:
an interface plate configured to secure the first ends of the respective signal transmission conduits in the first spatial arrangement;
a base configured to secure the second ends of the respective signal transmission conduits in the second spatial arrangement; and
and a side structure connecting the interface plate to the base at spaced-apart positions with respect to each other.

6. The apparatus of claim 5 , further comprising heat dissipating fins extending from the interface plate.

7. The apparatus of claim 1 , further comprising a signal coupling element operatively disposed with respect to the first end of each signal transmission conduit.

8. The apparatus of claim 1 , wherein each of the receptacles is in optical communication with a single signal transmission conduit.

9. The apparatus of claim 1 , wherein the processing module comprises an incubator.

10. The apparatus of claim 9 , further comprising:
an interface plate configured to secure the first ends of the respective signal transmission conduits in the first spatial arrangement, wherein the incubator is disposed on the interface plate; and
heat dissipating fins extending from the interface plate.

11. The apparatus of claim 10 , further comprising a fan to blow air across the heat dissipating fins.

12. The apparatus of claim 1 , further comprising a plurality of receptacle holders within the processing module, wherein the first end of each signal transmission conduit is coupled to an associated one of the receptacle holders.

13. The apparatus of claim 1 , further comprising one or more optical signal detectors, each optical signal detector being positioned or positionable with respect to the second ends of the respective signal transmission conduits and configured to emit an optical excitation signal that is transmitted from the second end of the transmission conduit to the first end of the transmission conduit and imparted to the contents of the associated receptacle and to receive an optical emission signal from the contents of the receptacle that is transmitted from the first end of the transmission conduit to the second end of the transmission conduit and convert the optical signal received to an electrical signal.

Assignees

• Gen Probe Inc

Inventors

• Hagen Norbert D
• Opalsky David

Classifications

• G02B6/08

  with fibre bundle in form of plate · CPC title

• G02B6/3672

  with fibres arranged in a regular matrix array · CPC title

• G01N21/6452

  Individual samples arranged in a regular 2D-array, e.g. multiwell plates · CPC title

• G01N2021/6484

  Optical fibres · CPC title

• G02B6/06

  the relative position of the fibres being the same at both ends, e.g. for transporting images · CPC title