Enzalutamide polymorphic forms and its preparation
US-9701641-B2 · Jul 11, 2017 · US
Production method of enzalutamide crystal form
US10118899B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10118899-B2 |
| Application number | US-201615577007-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 27, 2016 |
| Priority date | May 29, 2015 |
| Publication date | Nov 6, 2018 |
| Grant date | Nov 6, 2018 |
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Abstract
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The present invention aims to provided a novel production method of an enzalutamide crystal form in which wet crystals of enzalutamide are obtained in a step of crystallizing in the production process of the enzalutamide crystal form, and then 2-propanol which is solvated with enzalutamide and the B-type crystals are reduced. The present invention relates to a production method of an enzalutamide crystal form, which comprises a step of crystallizing for obtaining wet crystals of enzalutamide, and a step of drying the wet crystals, and comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of producing a crystal form of enzalutamide: comprising a step of crysallizing for obtaining wet crystals of enzalutamide and a step of drying the wet crystals, wherein the method comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing, wherein the good solvent is isopropyl acetate and the poor solvent is n-heptane.
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- C07D233/86Primary
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- What does patent US10118899B2 cover?
- The present invention aims to provided a novel production method of an enzalutamide crystal form in which wet crystals of enzalutamide are obtained in a step of crystallizing in the production process of the enzalutamide crystal form, and then 2-propanol which is solvated with enzalutamide and the B-type crystals are reduced. The present invention relates to a production method of an enzalutami…
- Who is the assignee on this patent?
- Astellas Pharma Inc, Astellas Pharma Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D233/86. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 06 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).