Combination of vaccination and inhibition of the PD-1 pathway

Patent metadata

Field	Value
Publication number	US-10117920-B2
Application number	US-201815890413-A
Country	US
Kind code	B2
Filing date	Feb 7, 2018
Priority date	Feb 22, 2013
Publication date	Nov 6, 2018
Grant date	Nov 6, 2018

Abstract

The present invention relates to a vaccine/inhibitor combination comprising an RNA vaccine comprising at least one RNA comprising at least one open reading frame (ORF) coding for at least one antigen and a composition comprising at least one PD-1 pathway inhibitor, preferably directed against PD-1 receptor or its ligands PD-L1 and PD-L2. The present invention furthermore relates to a pharmaceutical composition and a kit of parts comprising the components of such a vaccine/inhibitor combination. Additionally the present invention relates to medical use of such a vaccine/inhibitor combination, the pharmaceutical composition and the kit of parts comprising such a vaccine/inhibitor combination, particularly for the prevention or treatment of tumor or cancer diseases or infectious diseases. Furthermore, the present invention relates to the use of an RNA vaccine in therapy in combination with a PD-1 pathway inhibitor and to the use of a PD-1 pathway inhibitor in therapy in combination with an RNA vaccine.

First claim

The invention claimed is:

1. A method of treating a subject having a cancer or a tumor disease, the method comprising administering to the subject an effective amount of:
(i) an immunogenic composition comprising at least one mRNA comprising at least one open reading frame (ORF) encoding at least one tumor antigen, wherein the RNA is codon optimized for human codon usage, wherein the at least one mRNA comprises an increased G/C content relative to a wild-type RNA encoding the antigen; and
(ii) a PD-1 pathway inhibitor, wherein the PD-1 pathway inhibitor is an antagonistic antibody directed against PD-L1.

2. The method of claim 1 , wherein the at least one mRNA is complexed with a carrier.

3. The method of claim 2 , wherein the carrier is a cationic, polycationic or polymeric carrier.

4. The method of claim 3 , wherein the carrier comprises protamine.

5. The method of claim 3 , wherein the carrier comprises a cationic or polycationic lipid.

6. The method of claim 1 , wherein the PD-1 pathway inhibitor is administered after said immunogenic composition.

7. The method of claim 1 , wherein the immunogenic composition and the PD-1 pathway inhibitor are administered sequentially.

8. The method of claim 1 , wherein the immunogenic composition and the PD-1 pathway inhibitor are administered concurrently.

9. The method of claim 7 , wherein the immunogenic composition and the PD-1 pathway inhibitor are administered in the same composition.

10. The method of claim 1 , wherein the immunogenic composition and the PD-1 pathway inhibitor are administered via different administration routes.

11. A kit of parts comprising:
(i) an immunogenic composition comprising at least one mRNA comprising at least one open reading frame (ORF) encoding at least one tumor antigen, wherein the RNA is codon optimized for human codon usage, wherein the at least one mRNA comprises an increased G/C content relative to a wild-type RNA encoding the antigen; and
(ii) a composition comprising a PD-1 pathway inhibitor, wherein the PD-1 pathway inhibitor is an antagonistic antibody directed against PD-L1.

12. A pharmaceutical composition comprising an effective amount of:
(i) at least one mRNA comprising at least one open reading frame (ORF) encoding at least one tumor antigen, wherein the RNA is codon optimized for human codon usage and comprises an increased G/C content relative to a wild-type RNA encoding the antigen, and
(ii) a PD-1 pathway inhibitor, wherein the PD-1 pathway inhibitor is an antagonistic antibody directed against PD-L1.

Assignees

• Curevac Ag

Inventors

• Fotin-Mleczek Mariola
• Kallen Karl-Josef
• Probst Jochen

Classifications

• C07K16/28

  against receptors, cell surface antigens or cell surface determinants · CPC title

• A61K39/39558

  against tumor tissues, cells, antigens · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P31/10

  Antimycotics · CPC title

• A61P31/04

  Antibacterial agents · CPC title