Systems and methods for treatment of hearing using dihexa
US-2024424050-A1 · Dec 26, 2024 · US
US10117882B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10117882-B2 |
| Application number | US-84995010-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 4, 2010 |
| Priority date | May 5, 2006 |
| Publication date | Nov 6, 2018 |
| Grant date | Nov 6, 2018 |
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Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.
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The invention claimed is: 1. A gel capsule containing a lipid composition comprising a mixture of phospholipid molecules, having the following general structure: wherein said mixture of phospholipid molecules is characterized in comprising at least 1% docosahexaenoic acid (DHA) residues or eicosopentaenoic acid (EPA) residues at positions R1 or R2 and from 15 to 45% of OH at positions R1 or R2 and wherein R1 and R2 are not simultaneously —OH, wherein R3 is a moiety selected from the group consisting of choline, ethanolamine, inositol and serine moieties, and wherein said mixture of phospholipids is acylated in a range from 55% to about 85%. 2. The composition as claimed in claim 1 , wherein said mixture of phospholipids has a ratio of EPA/DHA ranging from 1:1 to 4:1. 3. The composition of claim 1 , wherein said mixture of phospholipids having a ratio of EPA/DHA ranging from 2:1 to 4:1. 4. The composition of claim 1 , wherein said composition further comprises a lipid carrier in a ratio of from 1:10 to 10:1 to said phospholipids. 5. The composition of claim 4 , wherein said lipid carrier is selected from the group consisting of a triglyceride, a diglyceride, fatty acid ethyl ester, and a fatty acid methyl ester and combinations thereof. 6. The composition of claim 4 , wherein said lipid carrier and said mixture of phospholipids are in a ratio of from about 5:1 to 1:5. 7. The composition of claim 4 , wherein said composition comprises from about 20% to about 90% of said mixture of phospholipids and from about 10% to about 50% of said lipid carrier.
Nutrients, e.g. vitamins, minerals · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Phosphatides, e.g. lecithin · CPC title
one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin · CPC title
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