Modified amino acids

Patent metadata

Field	Value
Publication number	US-10112900-B2
Application number	US-201715600632-A
Country	US
Kind code	B2
Filing date	May 19, 2017
Priority date	Aug 31, 2012
Publication date	Oct 30, 2018
Grant date	Oct 30, 2018

Abstract

Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

First claim

What is claimed is:

1. A compound according to formula I:

or a salt thereof, wherein:
D is Ar—W 3 — or —W 1 —Y 1 —C(O)—Y 2 —W 2 —;
Ar is

each of W 1 , W 2 , and W 3 is independently a single bond or lower alkylene;
X 1 is —O— or —S—;
Y 1 is a single bond, —NH—, or —O—;
Y 2 is an N-linked or C-linked divalent pyrrolidine radical; and
one of Z 1 , Z 2 , and Z 3 is —N— and the others of Z 1 , Z 2 , and Z 3 are independently —CH—.

2. The compound of claim 1 , wherein D is —Ar—W 3 —.

3. The compound of claim 1 , wherein D is —W 1 —Y 1 —C(O)—Y 2 —W 2 —.

4. The compound of claim 1 , wherein:
D is —Ar—W 3 —; and
Ar is

5. The compound of claim 1 , wherein:
D is —Ar—W 3 —; and
Ar is

6. The compound of claim 1 , wherein:
D is —Ar—W 3 —;
W 3 is —CH 2 —; and
Ar is

7. The compound of claim 1 wherein:
D is —W 1 —Y 1 —C(O)—Y 2 —W 2 —; and
Y 1 is —NH— or —O—.

8. The compound of claim 1 , wherein:
D is —W 1 —Y 1 —C(O)—Y 2 —W 2 —;
and
W 2 is a single bond.

9. The compound of claim 1 according to formula Ia:

10. The compound of claim 1 , wherein each of W 2 and W 3 is independently C 1 -C 3 alkylene.

11. The compound of claim 1 according to any of formulas (1)-(5), (7)-(17), (24)-(29), and 40:

or a salt thereof.

12. A compound according to formula II:

or a salt thereof, wherein W 4 is C 1 -C 10 alkylene.

13. The compound of claim 12 according to formula 30:

or a salt thereof.

Assignees

• Sutro Biopharma Inc

Inventors

• Stafford Ryan
• Thanos Christopher D
• Yang Wenjin

Classifications

• A61P37/02

  Immunomodulators · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• C07K14/535

  Granulocyte CSF; Granulocyte-macrophage CSF · CPC title

• C07C271/20

  to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups · CPC title