Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof

Patent metadata

Field	Value
Publication number	US-10111923-B2
Application number	US-201615128866-A
Country	US
Kind code	B2
Filing date	Apr 28, 2016
Priority date	Apr 29, 2015
Publication date	Oct 30, 2018
Grant date	Oct 30, 2018

Abstract

Compositions and preparation method thereof, said compositions comprise herb extract from a mixture comprising Cyclocarya paliurus leaf and one or two herbs selected from the group consisting of Puerariae lobatae Radix and Polygonati odorati Rhizoma, said compositions can treat diabetes, hyperglycemia, hypertension and/or hyperlipidemia.

First claim

What is claimed is:

1. A method for preparing an herbal extract composition comprising an extract of Cyclocarya paliurus , Puerariae lobatae Radix and Polygonati odorati Rhizoma, wherein the method comprises:
i) providing a mixture of Cyclocarya paliurus leaves, Puerariae lobatae Radix and Polygonati odorati Rhizoma, wherein said mixture comprises about 30-40% (w) Cyclocarya paliurus leaves, about 30-40% (w) Puerariae Radix and about 20-30% (w) Polygonati odorati Rhizoma;
ii) extracting said mixture with water to obtain an aqueous extract;
iii) concentrating the aqueous extract to obtain a concentrated mixture;
iv) obtaining a liquid portion of said concentrated mixture; and
v) drying said liquid portion to produce an herbal extract composition.

2. A method for preparing a granule comprising an herbal extract composition comprising an extract of Cyclocarya paliurus , Puerariae lobatae Radix and Polygonati odorati Rhizoma and an excipient, wherein said method comprises:
i) providing the herbal extract composition, wherein the herbal extract composition comprises about 30-40% (w) Cyclocarya paliurus leaves, about 30-40% (w) Puerariae Radix and about 20-30% (w) Polygonati odorati Rhizoma;
ii) mixing said herbal extract composition with an excipient to obtain a mixture;
iii) treating a portion of said mixture with an alcoholic solvent to obtain a wet granule; and
iv) drying the wet granule to obtain a dry granule.

3. The method according to claim 2 , wherein the excipient is mannitol.

4. The method according to claim 2 , wherein the alcoholic solvent is 95% ethanol.

5. The method of claim 2 , wherein the herbal extract composition comprises about 35% (w) Cyclocarya paliurus leaves, about 35% (w) Puerariae lobatae Radix and about 30% (w) Polygonati odorati Rhizoma.

6. The method of claim 2 , further comprising filtering the herbal extract through a filter.

7. The method of claim 2 , further comprising removing heavy metal from the herbal mixture.

Assignees

• Infinitus China Co Ltd

Inventors

• Ma Chung Wah
• Luo Zhen
• Zheng Xia
• Guo Xiaolei

Classifications

• A61K2236/13

  involving cleaning, e.g. washing or peeling · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61K36/8969

  Polygonatum (Solomon's seal) · CPC title

• A61K9/4866

  Organic macromolecular compounds · CPC title

• A61K2236/17

  involving drying, e.g. sun-drying or wilting · CPC title