Polymers for reversing heparin-based anticoagulation

Patent metadata

Field	Value
Publication number	US-10111902-B2
Application number	US-201514629408-A
Country	US
Kind code	B2
Filing date	Feb 23, 2015
Priority date	Jun 1, 2011
Publication date	Oct 30, 2018
Grant date	Oct 30, 2018

Abstract

Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

First claim

The invention claimed is:

1. A controlled release delivery device comprising:
a support having a surface;
a heparin binding polymer attached to the surface, the heparin binding polymer comprising:
a first dendritic polyol;
one or more cationic moieties, at least one of the one or more cationic moieties attached to the first dendritic polyol; and
at least one cleavage site; and
heparin bound to the heparin binding polymer, wherein the heparin binding polymer has the structure of Formula (I):

wherein L1, L2, L3, L4 and L5 comprise dendritic polyols.

2. The controlled release delivery device of claim 1 , wherein the surface forms part of a bead.

3. The controlled release delivery device of claim 1 , wherein the surface comprises a flat surface.

4. The controlled release delivery device of claim 1 , wherein the surface forms at least a portion of a cartridge.

5. The controlled release delivery device of claim 1 , wherein the heparin binding polymer is attached to the surface via an acetal bond or a ketal bond.

6. The controlled release delivery device of claim 1 , wherein the heparin binding polymer is attached to the surface via a disulfide bond.

7. The controlled release delivery device of claim 1 , wherein the heparin binding polymer comprises a protective moiety covalently attached to the first dendritic polyol.

8. The controlled release delivery device of claim 1 , wherein the heparin binding polymer comprises a second dendritic polyol, wherein the at least one cleavage site links the first dendritic polyol to the second dendritic polyol.

9. A controlled release delivery device comprising:
a support having a surface;
a heparin binding polymer attached to the surface, the heparin binding polymer comprising:
a first dendritic polyol;
one or more cationic moieties, at least one of the one or more cationic moieties attached to the first dendritic polyol; and
at least one cleavage site; and
heparin bound to the heparin binding polymer, wherein the heparin binding polymer has the structure of Formula (II):

wherein L1, L2, L3, and L4 comprise dendritic polyols.

10. The controlled release delivery device of claim 9 , wherein the surface forms part of a bead.

11. The controlled release delivery device of claim 9 , wherein the surface comprises a flat surface.

12. The controlled release delivery device of claim 9 , wherein the surface forms at least a portion of a cartridge.

13. The controlled release delivery device of claim 9 , wherein the heparin binding polymer is attached to the surface via an acetal bond or a ketal bond.

14. The controlled release delivery device of claim 9 , wherein the heparin binding polymer comprises a protective moiety covalently attached to the first dendritic polyol.

15. The controlled release delivery device of claim 9 , wherein the heparin binding polymer comprises a second dendritic polyol, wherein the at least one cleavage site links the first dendritic polyol to the second dendritic polyol.

Assignees

• Univ British Columbia

Inventors

• Kizhakkedathu Jayachandran N
• Shenoi Rajesh A
• Carter Cedric J
• Brooks Donald E

Classifications

• A61K31/785

  Polymers containing nitrogen · CPC title

• A61M2202/0413

  Blood · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title

• C08G73/024

  Polyamines containing oxygen in the form of ether bonds in the main chain · CPC title