Integrated condenser for collecting droplets

Patent metadata

Field	Value
Publication number	US-10111606-B2
Application number	US-201314372436-A
Country	US
Kind code	B2
Filing date	Jan 25, 2013
Priority date	Jan 25, 2012
Publication date	Oct 30, 2018
Grant date	Oct 30, 2018

Abstract

An integrated condenser is described. This integrated condenser includes an outer surface region on a sampler surface that facilitates condensing at least a component in a received gas-phase sample into liquid-phase droplets on the sampler surface, and aggregating and moving the condensed droplets radially toward an inner surface region on the sampler surface that receives the condensed droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient.

First claim

What is claimed is:

1. An integrated condenser, comprising:
a substrate; and
a sampler surface disposed on the substrate configured to receive a gas-phase sample, wherein the sampler surface further comprises:
an outer surface region configured to:
facilitate condensing at least a portion of the received gas-phase sample into liquid-phase droplets on the sampler surface; and
facilitate aggregating and moving the condensed droplets radially toward a center of the sampler surface;
wherein the outer surface region is micro-patterned to create a wettability gradient which is distributed axisymmetrically,
wherein the micro-pattern comprises a set of micro-patterned concentric rings,
wherein a given micro patterned concentric ring of the set of micro-patterned concentric rings comprises a set of radially oriented wall-groove pairs, and
wherein the number of wall-groove pairs in the given micro-patterned concentric ring increases from the outermost ring toward the innermost ring; and

an inner surface region within the outer surface region, wherein the inner surface region is configured to receive the condensed droplets collected by the outer surface region.

2. The integrated condenser of claim 1 , wherein the sampler surface is configured so that the sampler surface is increasingly less hydrophobic along a radial direction toward the center of the sampler surface.

3. The integrated condenser of claim 1 , wherein the wettability gradient increases in an inward radial direction.

4. The integrated condenser of claim 1 , wherein a wall within a given wall-groove pair has a trapezoidal cross-section.

5. The integrated condenser of claim 4 , wherein a base of the wall has a varying width which increases in an inward radial direction.

6. The integrated condenser of claim 1 , wherein the number of wall-groove pairs increases as a result of a decreasing width of the grooves from the outermost ring toward the innermost ring.

7. The integrated condenser of claim 1 , wherein the number of micro-patterned concentric rings is configured to control the wettability gradient of the outer surface region.

8. The integrated condenser of claim 1 , further comprising a hydrophobic coating disposed on the outer surface region to facilitate drop-wise condensation.

9. The integrated condenser of claim 8 , wherein the hydrophobic coating includes a super-hydrophobic thin film.

10. The integrated condenser of claim 1 , further comprising an active condensation mechanism configured to continuously cool the sampler surface to facilitate drop-wise condensation, wherein the active condensation mechanism includes a thermoelectric cooler.

11. The integrated condenser of claim 1 , further comprising an active condensation mechanism configured to adaptively cool the sampler surface to facilitate selected condensation of pre-defined biomarkers within certain temperature regimes.

12. The integrated condenser of claim 1 , wherein the substrate is a circular substrate.

13. The integrated condenser of claim 1 , wherein the substrate includes silicon.

14. An integrated condenser, comprising:
a substrate; and
a sampler surface disposed on the substrate configured to receive a breath sample that includes at least a gaseous-phase component, wherein the sampler surface further comprises:
an outer surface region configured to:
facilitate condensing the received sample into liquid-phase droplets on the sampler surface; and
facilitate aggregating and moving the condensed droplets radially toward a center of the sampler surface;
wherein the outer surface region comprises a set of micro-patterned concentric rings,
wherein a given micro patterned concentric ring of the set of micro-patterned concentric rings comprises a set of radially oriented wall-groove pairs, and
wherein the number of wall-groove pairs in the given micro-patterned concentric ring increases from the outermost ring toward the innermost ring; and

an inner surface region within the outer surface region, wherein the inner surface region is configured to receive the condensed droplets collected by the outer surface region.

15. The integrated condenser of claim 14 , wherein the sampler surface is configured so that the sampler surface is increasingly less hydrophobic along a radial direction toward the center of the sampler surface.

16. The integrated condenser of claim 14 , wherein the wettability gradient increases in an inward radial direction.

Assignees

• Univ California

Inventors

• Davis Cristina
• Bardaweel Hamzeh
• Zamuruyev Konstantin
• Delplanque Jean-Pierre
• Kenyon Nicholas J

Classifications

• G01N1/2202

  involving separation of sample components during sampling · CPC title

• G01N2001/2282

  with cooling means · CPC title

• A61B5/097 Primary

  Devices for facilitating collection of breath or for directing breath into or through measuring devices · CPC title

• A61B10/0051

  for taking saliva or sputum samples (devices for receiving spittle A61J9/00) · CPC title

• G01N33/497 Primary

  of gaseous biological material, e.g. breath · CPC title