System and method for determining radiation dose to circulating blood

Patent metadata

Field	Value
Publication number	US-10105555-B2
Application number	US-201515115153-A
Country	US
Kind code	B2
Filing date	Jan 30, 2015
Priority date	Jan 31, 2014
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

The present invention discloses systems and methods for calculating the radiation doses received by circulating blood cells. The present method may be applicable for calculating the radiation doses by circulating blood cells through any site in a patient. The present invention also discloses computer systems for calculating radiation doses received by circulating blood cells in a patient.

First claim

We claim:

1. A non-transitory, computer readable storage medium having instructions stored thereon that, when executed by a computer processor, cause the computer processor to:
receive medical imaging data from a subject including information about a treatment site receiving a dose of radiation;
receive a plurality of subject/treatment-specific variables including at least two of a target volume size associated with the dose of radiation, a radiation treatment technique associated with the dose of radiation, a dose rate associated with the dose of radiation, a total dose associated with the dose of radiation, a fraction size associated with the dose of radiation, a treatment time associated with delivering the dose of radiation, a speed of circulating blood within the subject, and a presence of vasculature relative to the treatment site; and
determine using the plurality of subject/treatment-specific variables a quantity of radiation received by circulating blood within the subject when receiving the dose of radiation.

2. The computer readable storage medium of claim 1 , further comprising generating a report indicating the quantity of radiation received by circulating blood within the subject.

3. The computer readable storage medium of claim 1 , further comprising determining organs within the subject that are at risk of being subjected to an undesired dose of radiation due to the radiation received by circulating blood within the subject.

4. The computer readable storage medium of claim 1 , further comprising creating a tumor volume within the site using the medical imaging data.

5. The computer readable storage medium of claim 4 , further comprising determining a dose of radiation delivered to the site using the tumor volume.

6. The computer readable storage medium of claim 5 , further comprising determining a dose of radiation delivered to the site using the tumor volume.

7. The computer readable storage medium of claim 6 , further comprising generating a three-dimensional dose grid for the site.

8. The computer readable storage medium of claim 7 , further comprising using the three-dimensional dose grid for the site, calculating a mean dose of radiation to a blood pool within the site.

9. The computer readable storage medium of claim 8 , further comprising quantifying a total volume of blood receiving radiation.

10. A method for calculating radiation doses received by circulating blood cells in a patient comprising the steps of:
a) obtaining medical imaging data of a site in a patient;
b) creating a tumor volume within the site using the medical imaging data;
c) determining a dose of radiation delivered to the site using the tumor volume;
d) generating a three-dimensional dose grid for the site;
e) using the three-dimensional dose grid for the site, calculating a dose of radiation to a blood pool within the site;
f) quantifying a dose relationship in a dose volume histogram; and
g) generating a report indicating the dose of radiation received by circulating blood using the quantification in step f).

11. The method of claim 10 , wherein the tumor volume is spherical.

12. The method of claim 10 , wherein step e) includes determining a size of the tumor volume and number of radiation fractions received by the tumor volume.

13. The method of claim 12 , wherein step f) includes applying a model that uses radiation fractions received by the tumor volume to quantify the total volume of blood receiving radiation.

14. The method of claim 10 , further comprising determining a radiation treatment technique used to deliver the dose of radiation, a dose rate used to deliver the dose of radiation, a treatment time used to deliver the dose of radiation, a speed of circulating blood within the subject, and a of major vasculature proximate to at least one of the tumor volume and the site.

15. The method of claim 10 , wherein the medical imaging data includes at least one of magnetic resonance imaging (MRI) data and computed tomography (CT) data.

16. A computer system for calculating radiation doses received by circulating blood cells in a patient, the computer system comprising:
a) an input interface unit to load pre-obtained medical imaging data of a site in a patient into the system,
b) a processor configured to carry on the steps of:
(1) creating a tumor volume within the site using the medical imaging data;
(2) determining a dose of radiation delivered to the site using the tumor volume;
(3) generating a three-dimensional dose grid for the site;
(4) calculating a dose of radiation to a blood pool within the site;
(5) quantifying a total volume of blood receiving radiation; and

c) a display to display a report of radiation doses received by circulating blood cells in a patient.

17. The computer system of claim 16 , wherein the tumor volume is spherical.

18. The computer system of claim 16 , wherein step 4 ) includes determining a size of the tumor volume and number of radiation fractions received by the tumor volume.

19. The computer system of claim 16 , wherein step 5 ) includes applying a model that uses radiation fractions received by the tumor volume to quantify the total volume of blood receiving radiation.

20. The computer system of claim 16 , wherein the steps carried by the processor further comprising determining a radiation treatment technique used to deliver the dose of radiation, a dose rate used to deliver the dose of radiation, a treatment time used to deliver the dose of radiation, a speed of circulating blood within the subject, and a major vasculature proximate to at least one of the tumor volume and the site.

21. The computer system of claim 16 , wherein the medical imaging data includes at least one of magnetic resonance imaging (MRI) data and computed tomography (CT) data.

Assignees

• Univ Johns Hopkins

Inventors

• Ellsworth Susannah
• Ford Eric
• Grossman Stuart A
• Hobbs Robert
• Kleinberg Lawrence

Classifications

• A61N5/1071 Primary

  for verifying the dose delivered by the treatment plan · CPC title