Micronized placental tissue compositions and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-10105397-B2
Application number	US-201313787612-A
Country	US
Kind code	B2
Filing date	Mar 6, 2013
Priority date	Feb 14, 2011
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

First claim

What is claimed:

1. A micronized composition comprising micronized particles, said particles comprising an amnion layer and a chorion layer; wherein the chorion layer is layered directly over the amnion layer, and further wherein the amnion layer has an exposed basement membrane and an exposed intact fibroblast layer; wherein an intermediate layer of said amnion layer has been substantially removed, and wherein an epithelial layer of said amnion layer has been substantially removed.

2. The micronized composition of claim 1 , further comprising micronized amnion.

3. The micronized composition of claim 1 , further comprising one or more additional layers selected from the group consisting of amnion, chorion, intermediate tissue layer, allograft pericardium, allograft acellular dermis, Wharton's jelly, purified xenograft Type-I collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, and any combination thereof.

4. The micronized composition of claim 1 , wherein the micronized particles are dehydrated.

Assignees

• Mimedx Group Inc

Inventors

• Morse Brenda S
• Sith Somaly
• Spencer Randall
• Ray Steven
• Daniel John
• Tofe Robert

Classifications

• A61K35/50 Primary

  Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells · CPC title

• A61L27/3604

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61K8/982

  Reproductive organs; Embryos, Eggs · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title