Apparatus for optical analysis of an associated tissue

Patent metadata

Field	Value
Publication number	US-10105057-B2
Application number	US-201113995967-A
Country	US
Kind code	B2
Filing date	Dec 22, 2011
Priority date	Jan 4, 2011
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

First claim

The invention claimed is:

1. An apparatus for optical analysis of an associated non-fluid tissue of an organ of a subject, the apparatus comprising:
a spectrometer for obtaining measured data representative of an optical spectrum of the associated non-fluid tissue of the organ of the subject, the spectrometer comprising
a light source,
an optical detector,
a processor, and
a database, which database is operably connected to the processor, wherein the database comprises predetermined data representative of an optical spectrum of human bile,
wherein the processor is arranged for
receiving the measured data,
determining from the measured data and the predetermined data representative of an optical spectrum of human bile a first parameter being indicative of a concentration of bile in said associated non-fluid tissue of the organ of the subject, and
determining from the first parameter a second parameter being indicative of a tissue type for the associated non-fluid tissue of the organ of the subject.

2. An apparatus according to claim 1 , wherein the processor is further arranged for determining a scattering parameter based on the measured data.

3. An apparatus according to claim 1 , further comprising an interventional device, the interventional device comprising
a first guide for guiding photons from the light source to an exit position on a distal end of the interventional device, the photons being emittable from the exit position, and
a second guide for guiding photons from an entry position on the distal end of the interventional device and to the optical detector.

4. An apparatus according to claim 3 , wherein the exit position and the entry position are spatially separated and spatially oriented so that, upon positioning the distal end of the interventional device adjacent to the associated tissue, an average spectral information of a region of the associated non-fluid tissue is obtainable from photons collectable at the entry position.

5. An apparatus according to claim 3 , wherein the photons exiting the second guide are non-focused.

6. An apparatus according to claim 1 , wherein the apparatus further comprises any one of: a second light source for providing therapeutic light and/or an ultrasound unit.

7. An apparatus according to claim 1 , wherein the second parameter indicative of tissue type enables discrimination between tissue conditions.

8. An apparatus according to claim 1 , wherein the second parameter indicative of tissue type enables discrimination between dysplastic tissue and normal tissue.

9. An apparatus according to claim 1 , wherein the second parameter indicative of tissue type enables discrimination between normal tissue and tumor tissue.

10. A method for optical analysis of an associated non-fluid tissue of an organ of a subject, the method comprising the steps of:
receipt of measured data representative of an optical spectrum of the associated non-fluid tissue of the organ of the subject,
determination of a first parameter, the first parameter being indicative of a concentration of bile, based on the measured data and predetermined data representative of an optical spectrum of human bile, and
determination of a second parameter based on the first parameter, the second parameter being indicative of a tissue type for the associated non-fluid tissue of the organ of the subject.

11. A method according to claim 10 for optical analysis of an associated tissue, wherein the determination of the first parameter includes fitting the measured data to a mathematical model.

12. A method according to claim 10 for optical analysis of an associated non-fluid tissue, wherein the determination of the first parameter includes any one of:
assessing a look-up-table comprising predetermined optical spectra, and
performing multivariate analysis.

13. A method according to claim 10 for optical analysis of an associated non-fluid tissue, the method further including the step of:
determination of a ratio between a concentration of biliverdin and a concentration of bilirubin.

14. A method according to claim 10 for optical analysis of an associated non-fluid tissue, the method further comprising the step of:
determination of a concentration of cholesterol.

15. A non-transitory computer readable medium storing a computer program product adapted to enable a computer to carry out the method of claim 10 .

Assignees

• Hendriks Bernardus Hendrikus Wilhelmus
• Nachabe Rami
• Lucassen Gerhardus Wilhelmus
• Desjardins Adrien Emmanuel
• Ruers Theodoor Jacques Marie
• Koninklijke Philips Nv

Inventors

• Hendriks Bernardus Hendrikus Wilhelmus
• Nachabe Rami
• Lucassen Gerhardus Wilhelmus
• Desjardins Adrien Emmanuel
• Ruers Theodoor Jacques Marie

Classifications

• A61B5/0036 Primary

  including treatment, e.g., using an implantable medical device, ablating, ventilating · CPC title

• G01N21/25

  Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands · CPC title

• A61B1/00

  Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes (examination of body cavities or body tracts using ultrasonic, sonic or infrasonic waves A61B8/12; endoscopic instruments for taking cell samples or for biopsy A61B10/04); Illuminating arrangements therefor (for the eyes A61B3/00) · CPC title

• A61B18/18

  by applying electromagnetic radiation, e.g. microwaves · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title