Biomarkers for diabetes and usages thereof

Patent metadata

Field	Value
Publication number	US-10100360-B2
Application number	US-201314418800-A
Country	US
Kind code	B2
Filing date	Jun 5, 2013
Priority date	Aug 1, 2012
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

Biomarkers for diabetes and usages thereof are provided. And the biomarkers are nucleotides having polynucleotide sequences defined in SEQ ID NOs: 1-50.

First claim

What is claimed is:

1. A method of determining Type 2 Diabetes in a subject comprising:
(a) determining a relative abundance of one or more polynucleotides in a gut microbiota of the subject, wherein (i) the one or more polynucleotides are selected from polynucleotides comprising a sequence selected from SEQ ID NOs: 1 to 50;
(b) determining a gut healthy index for the subject determined according to the relative abundance determined in (a), and
(c) determining the presence of Type 2 diabetes in the subject according to the gut healthy index.

2. The method of claim 1 , wherein step (a) comprises determining the relative abundance of each of the polynucleotides comprising a sequence of SEQ ID NOs: 1 to 50.

3. The method of claim 1 or 2 , wherein the presence of Type 2 diabetes in the subject is determined by a gut healthy index greater than 0.046.

Assignees

• Bgi Shenzhen
• Bgi Shenzhen Co Ltd

Inventors

• Li Shenghui
• Feng Qiang
• Jie Zhuye
• Zhang Dongya
• Qin Junjie
• Wang Jun
• Wang Jian
• Yang Huanming

Classifications

• C12Q2600/158

  Expression markers · CPC title

• C12Q1/6883 Primary

  for diseases caused by alterations of genetic material · CPC title

• G16B30/00

  ICT specially adapted for sequence analysis involving nucleotides or amino acids · CPC title

• C12Q2600/112

  Disease subtyping, staging or classification · CPC title

• G16H50/20

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title