Compositions and methods that inhibit il-23 signaling
US-2024425579-A1 · Dec 26, 2024 · US
Maternal TH17 cells and psychiatric disorders
US10100113B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10100113-B2 |
| Application number | US-201615042976-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 12, 2016 |
| Priority date | Feb 13, 2015 |
| Publication date | Oct 16, 2018 |
| Grant date | Oct 16, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus at risk. Also encompassed herein is a method for treating a fetus in utero to reduce the risk of abnormal cortical development that arises from Th17 cell-mediated activity.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for reducing the risk of developing autism spectrum disorder in a fetus, the method comprising administering an inhibitor of T helper 17 (Th17) cell activity to a pregnant female, wherein the inhibitor of T helper 17 (Th17) cell activity is an antibody specific for IL-17a or IL-17 receptor, and wherein the pregnant female is carrying the fetus in utero. 2. The method of claim 1 , wherein the autism spectrum disorder is autism. 3. The method of claim 1 , wherein the inhibitor of Th17 cell activity is administered to the female in the first, second, or third trimester of the pregnancy. 4. The method of claim 1 , further comprising assaying IL-17a levels in a sample isolated from the pregnant female. 5. The method of claim 4 , wherein the sample is whole blood, sera, or amniotic fluid. 6. The method of claim 1 , wherein the pregnant female was or is afflicted with a hyper-inflammatory condition during the pregnancy with the fetus, wherein the hyper-inflammatory condition is associated with a viral or bacterial infection or exposure to an inflammatory or environmental toxin during the pregnancy with the fetus. 7. The method of claim 1 , wherein the pregnant female has given birth to at least one offspring afflicted with a autism spectrum disorder in a previous pregnancy.
Assignees
Inventors
Classifications
Psychoses; Psychiatry · CPC title
against receptors for cytokines, lymphokines, interferons · CPC title
Expression markers · CPC title
- C07K16/244Primary
Interleukins [IL] · CPC title
Interleukin · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10100113B2 cover?
- Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus at risk. Also encompassed herein is a method for treating a fetus in utero to reduce the risk of abnormal cortical developme…
- Who is the assignee on this patent?
- Littman Dan R, Huh Jun R, Univ New York
- What technology area does this patent fall under?
- Primary CPC classification C07K16/244. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).