Anti-activin A antibodies and uses thereof

Patent metadata

Field	Value
Publication number	US-10100109-B2
Application number	US-201615346617-A
Country	US
Kind code	B2
Filing date	Nov 8, 2016
Priority date	Sep 8, 2006
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

First claim

The invention claimed is:

1. An isolated anti-human activin A antibody or antigen binding fragment thereof, comprising:
a. a light chain variable domain (VL) comprising:
i. a light chain CDR1 sequence of SEQ ID NO:43;
ii. a light chain CDR2 sequence of SEQ ID NO:44; and
iii. a light chain CDR3 sequence of SEQ ID NO:45; and

b. a heavy chain variable domain (VH) comprising:
i. a heavy chain CDR1 sequence of SEQ ID NO:46;
ii. a heavy chain CDR2 sequence of SEQ ID NO:47; and
iii. a heavy chain CDR3 sequence of SEQ ID NO:48.

2. An isolated anti-human activin A antibody or antigen binding fragment thereof, comprising:
(a) a variable light chain sequence comprising SEQ ID NO: 41 and
(b) a variable heavy chain sequence comprising SEQ ID NO: 42.

Assignees

• Amgen Inc

Inventors

• Han Huiquan
• Chen Qing
• Kwak Keith Soo-Nyung
• Zhou Xiaolan

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P5/06

  of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH · CPC title

• A61P5/00

  Drugs for disorders of the endocrine system · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title