Compound for labeling mitochondria and method of producing the same

US10100065B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-10100065-B2
Application numberUS-201715479150-A
CountryUS
Kind codeB2
Filing dateApr 4, 2017
Priority dateMay 11, 2016
Publication dateOct 16, 2018
Grant dateOct 16, 2018

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

In Chemical Formulas 1 and 2, n is 4 or 10.

First claim

Opening claim text (preview).

What is claimed is: 1. A compound represented by Chemical Formula 1 or Chemical Formula 2 below: in Chemical Formulas 1 and 2, n is 4 or 10. 2. A method of producing a compound for labeling mitochondria, comprising: reacting a compound represented by Chemical Formula 3 below with acetonitrile, potassium iodide and pyridine, thus forming a compound represented by Chemical Formula 1 below: in Chemical Formulas 1 and 3, n is 4 or 10. 3. A method of producing a compound for labeling mitochondria, comprising: reacting a compound represented by Chemical Formula 3 below with acetonitrile, potassium iodide and triphenylphosphine, thus forming a compound represented by Chemical Formula 2 below: in Chemical Formulas 2 and 3, n is 4 or 10. 4. The method of claim 2 , wherein the compound represented by Chemical Formula 3 is formed by reacting a compound represented by Chemical Formula 4 below with methylene chloride, 2,4-dimethylpyrrole, phosphoryl chloride, boron trifluoride etherate, and diisopropylethylamine: in Chemical Formula 4, n is 4 or 10. 5. The method of claim 4 , wherein the compound represented by Chemical Formula 4 is formed by reacting a compound represented by Chemical Formula 5 below with dimethylformamide, phosphoryl chloride, dichloroethane, and sodium acetate: in Chemical Formula 5, n is 4 or 10. 6. The method of claim 5 , wherein the compound represented by Chemical Formula 5 is formed by dissolving acetophenone and (bromoalkoxy)benzaldehyde in ethanol, performing stirring, further adding lithium hydroxide monohydrate and tosylmethyl isocyanide, and performing stirring until a precipitate is generated. 7. A method of labeling mitochondria comprising dissolving the compound represented by Chemical Formula 1 or 2 of claim 1 in a solvent to give a solution and adding the solution to a sample containing cells.

Assignees

Inventors

Classifications

  • Dyes containing an onium group attached to the dye skeleton via a bridge · CPC title

  • containing nitrogen as the only heteroatom · CPC title

  • containing organic luminescent materials · CPC title

  • bridged by heteroatoms, e.g. N, P, Si or B · CPC title

  • containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings · CPC title

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Frequently asked questions

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What does patent US10100065B2 cover?
In Chemical Formulas 1 and 2, n is 4 or 10.
Who is the assignee on this patent?
Korea Inst Sci & Tech
What technology area does this patent fall under?
Primary CPC classification C07F5/027. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Oct 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).