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US-2024425484-A1 · Dec 26, 2024 · US
Lappaconitine aza-cinnamic acid derivatives with anti-tumor activities and a method of preparing the same
US10100036B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10100036-B2 |
| Application number | US-201715713934-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 25, 2017 |
| Priority date | Sep 30, 2016 |
| Publication date | Oct 16, 2018 |
| Grant date | Oct 16, 2018 |
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Abstract
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A lappaconitine aza-cinnamic acid derivative having the following formula (I): X is C or N, and R 1 , R 2 , and R 3 are independently H or lower alkyl. A method of preparing the lappaconitine aza-cinnamic acid derivative of formula (I) is also disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A lappaconitine aza-cinnamic acid derivative selected from the group consisting of 2. A method of preparing lappaconitine Aza-cinnamic acid derivatives with antitumor activities comprising: reacting a compound of formula (II): with HCl to obtain a compound of formula (III): and reacting the compound of formula (III) with a compound of formula (IV): to obtain a lappaconitine aza-cinnamic acid derivative having the following formula (I): wherein X is C or N, and R 1 , R 2 , and R 3 are independently H or lower alkyl. 3. The method of claim 2 , wherein the compound of formula (II) reacts with 2% HCl in ethanol in a molar ratio of 1:5. 4. The method of claim 2 , wherein the compound of formula (III) reacts with the compound of formula (IV) in DMF in a molar ratio of 1:1.1-12 with DCC as a catalyst. 5. The method of claim 4 , wherein the compound of formula (III) reacts with the compound of formula (IV) at 50° C.-90° C. 6. The method of claim 4 , wherein the compound of formula (III) reacts with the compound of formula (IV) at 60° C.-80° C.
Assignees
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Classifications
- C07D401/12Primary
linked by a chain containing hetero atoms as chain links · CPC title
Antineoplastic agents · CPC title
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Frequently asked questions
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- What does patent US10100036B2 cover?
- A lappaconitine aza-cinnamic acid derivative having the following formula (I): X is C or N, and R 1 , R 2 , and R 3 are independently H or lower alkyl. A method of preparing the lappaconitine aza-cinnamic acid derivative of formula (I) is also disclosed.
- Who is the assignee on this patent?
- Liang Chengyuan, Jia Minyi, Ju Xingke, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C07D401/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).