Implant and method for producing the same

Patent metadata

Field	Value
Publication number	US-10098765-B2
Application number	US-201113306412-A
Country	US
Kind code	B2
Filing date	Nov 29, 2011
Priority date	Dec 15, 2010
Publication date	Oct 16, 2018
Grant date	Oct 16, 2018

Abstract

The present invention relates to an implant ( 10 ), and particularly to an intraluminal endoprosthesis, comprising a body and at least one abluminal layer ( 3 ) disposed on the body, the abluminal layer preferably containing at least one pharmaceutically active substance. In order to protect the abluminal layer ( 3 ) from delamination or shearing, the abluminal layer ( 3 ) is additionally fastened to the implant body at least in a transition region ( 7 ) by way of at least one anchoring layer ( 5 ) disposed on the abluminal layer ( 3 ). In addition, methods for producing such an implant are described.

First claim

What is claimed is:

1. An implant in the form of an intraluminal endoprosthesis, comprising:
a body;
an abluminal layer disposed on the abluminal surface of the body and formed from a polymer formulation, wherein the abluminal layer optionally contains at least one pharmaceutically active substance; and
an anchoring layer disposed on the luminal surface of the body and formed from a different polymer formulation that degrades more quickly in vivo than the polymer formulation forming the abluminal layer, wherein opposing ends of the anchoring layer are coupled to opposing ends of the abluminal layer at opposing transition regions, further wherein the abluminal layer is absent from the luminal surface between the opposing transition regions and the anchoring layer is absent from the abluminal surface between the opposing transition regions.

2. The implant according to claim 1 , characterized in that the transition regions are less than 30% of the total surface of the abluminal layer.

3. The implant according to claim 1 , characterized in that the anchoring layer extends in the luminal region of the implant.

4. The implant according to claim 1 , characterized in that the abluminal layer is degradable.

5. The implant according to claim 1 , characterized in that the abluminal layer is joined to the anchoring layer in the transition region by a bond, a positive engagement or both.

6. The implant according to claim 1 , characterized in that n abluminal layers are disposed in the transition region between two of the n+1 anchoring layers, with n>=1 and n being an integer.

7. The implant according to claim 1 , characterized in that a further coating is disposed on at least part of the surface of the anchoring layer, the further coating optionally comprising one or more selected from of the group consisting of an endothelial cell capturing technology, an endothelialization promoter and an endothelialization-promoting surface.

8. The implant according to claim 1 , further comprising a second anchoring layer, wherein the abluminal layer is embedded within both anchoring layers at the transition regions.

9. An implant according to claim 1 , wherein the abluminal layer is fastened at the opposing transition regions.

10. An implant in the form of an intraluminal endoprosthesis, comprising:
a body;
an abluminal layer disposed on the abluminal surface of the body and formed from a polymer formulation, wherein the abluminal layer optionally contains at least one pharmaceutically active substance; and
an anchoring layer disposed on the luminal surface of the body and formed from a different polymer formulation than the polymer formulation of the abluminal layer, wherein opposing ends of the abluminal layer and anchoring layer are partially dissolved into one another at opposing transition regions, further wherein the abluminal layer is absent from the luminal surface between the opposing transition regions and the anchoring layer is absent from the abluminal surface between the opposing transition regions.

11. The implant according to claim 10 , characterized in that the transition regions are less than 30% of the total surface of the abluminal layer.

12. The implant according to claim 10 , characterized in that n abluminal layers are disposed in the opposing transition regions between two of n+1 anchoring layers, with n>=1 and n being an integer.

13. The implant according to claim 10 , characterized in that a further coating is disposed on at least part of the surface of the anchoring layer, the further coating comprising one or more selected from of the group consisting of an endothelial cell capturing technology, an endothelialization promoter and an endothelialization-promoting surface.

Assignees

• Klocke Bjoern
• Borck Alexander
• Biotronik Ag

Inventors

• Klocke Bjoern
• Borck Alexander

Classifications

• A61F2210/0076

  multilayered, e.g. laminated structures · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title

• A61F2/91 Primary

  made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes · CPC title

• A61F2/86 Primary

  Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure · CPC title