System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US10098698B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10098698-B2 |
| Application number | US-201715678632-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 16, 2017 |
| Priority date | Dec 15, 2010 |
| Publication date | Oct 16, 2018 |
| Grant date | Oct 16, 2018 |
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A probe tip for communicating and laterally directing electromagnetic radiation comprises a waveguide, a primary capsule, a compressible member and a malleable secondary capsule. The waveguide is configured to communicate electromagnetic radiation and includes a beveled surface at a distal tip for redirecting electromagnetic radiation in a lateral direction. The primary capsule is attached over the distal tip of the waveguide. The compressible member covers a portion of the primary capsule. The malleable secondary capsule is positioned over the primary capsule and the compressible member, and includes a crimp that compresses the compressible member against the primary capsule and secures the secondary capsule to the primary capsule.
Opening claim text (preview).
What is claimed is: 1. A method, comprising: producing electromagnetic radiation using a laser resonator; transmitting the electromagnetic radiation from the laser resonator to a probe tip, wherein the probe tip includes a distal end of a waveguide, a primary capsule attached to the distal end of the waveguide, a secondary capsule positioned at least partially over the primary capsule, and at least one crimp on a proximal end of the secondary capsule to secure the secondary capsule to at least one of the primary capsule or the waveguide; positioning the probe tip in a first fluid flow channel, wherein the first fluid channel extends distally of the crimp; allowing fluid to flow into a second fluid flow channel between the primary capsule and the secondary capsule; and delivering electromagnetic radiation to tissue. 2. The method of claim 1 , wherein the secondary capsule includes a proximal end portion, a distal end portion, and an outlet port between the proximal and distal end portions. 3. The method of claim 1 , wherein the at least one crimp includes an annular dent in the secondary capsule that extends towards the primary capsule. 4. The method of claim 1 , wherein the at least one crimp includes at least one tab. 5. The method of claim 1 , wherein the second fluid flow channel extends from the proximal end of the secondary capsule to an outlet port on a lateral portion of the secondary capsule. 6. The method of claim 1 , wherein the secondary capsule includes a malleable material. 7. The method of claim 1 , wherein the step of delivering electromagnetic radiation to tissue includes discharging the electromagnetic radiation in a lateral direction relative to a longitudinal axis of the optical fiber. 8. A method, comprising: producing electromagnetic radiation using a laser resonator; transmitting the electromagnetic radiation from the laser resonator to a probe tip, wherein the probe tip includes a distal end of a waveguide, a primary capsule having a transmissive surface, wherein the secondary capsule includes an outlet port on a first side and is secured to at least one of the waveguide or the primary capsule by a crimp, and wherein the crimp is formed by at least one deformable member positioned on a proximal end of the secondary capsule and on the first side of the secondary capsule; positioning at least a portion of the probe tip in a first fluid flow channel of a medical device; allowing fluid to flow into a second fluid flow channel between the primary capsule and the secondary capsule; and delivering electromagnetic radiation to tissue. 9. The method of claim 8 , wherein: a back side of the primary capsule, which is opposite a front side of the primary capsule, is pressed against a back side of the secondary capsule; and the second fluid flow channel is formed between the front side of the primary capsule and a front side of the secondary capsule. 10. The method of claim 8 , wherein the second fluid flow channel extends from the proximal end of the secondary capsule to an outlet port of the secondary capsule. 11. The method of claim 8 , wherein the waveguide includes a protective layer, and wherein the crimp compresses the protective layer. 12. The method of claim 8 , wherein a distal end of the waveguide includes a beveled surface that is non-perpendicular to a longitudinal axis of the waveguide. 13. The method of claim 8 , wherein the step of positioning at least a portion of the probe tip in a first fluid flow channel of the medical device includes positioning at least a portion of the probe tip in the first fluid flow channel of at least one of an endoscope or cystoscope. 14. The method of claim 8 , further comprising a compressible member positioned between the primary capsule and the secondary capsule. 15. A method, comprising: providing a medical device including a probe tip, wherein the probe tip includes a distal end of an optical fiber, a primary capsule attached to the distal end of the optical fiber, and a secondary capsule positioned at least partially over the primary capsule, wherein the secondary capsule is secured relative to the primary capsule by a crimp on a proximal end of the secondary capsule and a portion of the probe tip is in a first fluid flow channel distal to the crimp; producing electromagnetic radiation; transmitting the electromagnetic radiation to the probe tip; allowing fluid to flow into a second fluid flow channel of the probe tip; and discharging electromagnetic radiation from the probe tip. 16. The method of claim 15 , wherein the step of providing the medical device further includes that the crimp includes a tab proximate the proximal end of the secondary capsule. 17. The method of claim 15 , wherein the step of providing the medical device further includes that the crimp includes a deformation in the secondary capsule that extends towards the primary capsule. 18. The method of claim 15 , wherein the step of providing the medical device further includes that the secondary capsule includes a tubular sleeve having an open proximal end and an open distal end. 19. The method of claim 15 , wherein the step of discharging electromagnetic radiation includes discharging the electromagnetic radiation in a lateral direction relative to a longitudinal axis of the optical fiber. 20. The method of claim 15 , wherein the step of providing the medical device further includes that the optical fiber includes a protective layer, and wherein the crimp compresses the protective layer.
Electromagnet, transformer or inductor · CPC title
with reflective or refractive surfaces for deflecting the beam (A61B2018/2261, A61B2018/2266 take precedence) · CPC title
the beam being directed along or through a flexible conduit, e.g. an optical fibre; {Couplings or} hand-pieces therefor · CPC title
Joined to rod · CPC title
Optical elements at the distal end of probe tips · CPC title
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