Biomarker of renal dysfunction

Patent metadata

Field	Value
Publication number	US-10094839-B2
Application number	US-201314407760-A
Country	US
Kind code	B2
Filing date	Jun 13, 2013
Priority date	Jun 14, 2012
Publication date	Oct 9, 2018
Grant date	Oct 9, 2018

Abstract

The present invention relates to a method for a method for predicting the development of renal dysfunction in a subject following physical trauma, hypotension, sepsis and/or septic shock syndrome, wherein the method comprises the steps of: —a. determining the level of an anti-inflammatory cytokine present in a sample taken from the subject after physical trauma, after a hypotensive event, after sepsis, and/or after septic shock syndrome; b. predicting the development in the subject of renal dysfunction on the basis of the level of an anti-inflammatory cytokine determined in step a).

First claim

The invention claimed is:

1. A method of treating a subject at increased risk of renal dysfunction induced by at least one of physical trauma, hypotension, sepsis, and septic shock syndrome, wherein the method includes the step of:
a) obtaining a urine sample from a subject after the at least one of physical trauma, hypotension, sepsis and septic shock syndrome;
b) detecting the anti-inflammatory cytokine present in the urine sample obtained in step a), wherein the anti-inflammatory cytokine is selected from the group consisting of IL-1ra, TNFsr1 and TNFsr2 and any combination thereof;
c) detecting the anti-inflammatory cytokine in a post-event normal control;
d) calculating the level of anti-inflammatory cytokine detected in step b) relative to the level of anti-inflammatory cytokine detected in step c);
e) determining that the subject has a greater than normal chance of developing renal dysfunction induced by physical trauma, hypotension, sepsis and/or septic shock syndrome when the level of anti-inflammatory cytokine determined in step b) is lower than the level of anti-inflammatory cytokine detected in step c); and
f) applying therapeutic measures to treat or obviate the predicted impending renal dysfunction to the subject wherein the therapeutic measures are selected from maintaining a supra-normal blood pressure; ensuring adequate tissue oxygen delivery; administration of steroids; renal replacement therapy; dialysis; or any combination thereof.

Assignees

• Univ Belfast
• Belfast Health And Social Care Trust

Inventors

• Mcbride William Thomas
• Armstrong Marilyn

Classifications

• G01N33/6863 Primary

  Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors · CPC title

• G01N2333/545

  IL-1 · CPC title

• G01N2333/525

  Tumor necrosis factor [TNF] · CPC title

• A61B5/201

  Assessing renal or kidney functions · CPC title

• G01N2800/347

  Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy · CPC title