Antigen composition for detecting chagas disease
US-2017248597-A1 · Aug 31, 2017 · US
Antigen composition for detecting Chagas disease
US10094828B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10094828-B2 |
| Application number | US-201715587842-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 5, 2017 |
| Priority date | Nov 6, 2014 |
| Publication date | Oct 9, 2018 |
| Grant date | Oct 9, 2018 |
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Abstract
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The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi ( T. cruzi ) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition of polypeptides suitable for detecting antibodies agains Trypanosoma cruzi in an isolated biological sample, said composition comprising three recombinantly or synthetically produced polypeptides specific for Trypanosoma cruzi , wherein said polypeptides are selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. 2. A composition of polypeptides according to claim 1 wherein said composition comprises calcium ions in a concentration of 0.1 to 10 millions per liter. 3. A reagent kit for the detection of anti- Trypanosoma cruzi antibodies, comprising a composition of Trypanosoma cruzi polypeptides according to claim 1 .
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Classifications
Detection of antibodies in sample from host which are directed against antigens from microorganisms · CPC title
from protozoa · CPC title
- G01N33/56905Primary
Protozoa · CPC title
Trypanosoma antigens · CPC title
for pre-existing immune complex or autoimmune disease {, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9} · CPC title
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- What does patent US10094828B2 cover?
- The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi ( T. cruzi ) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides …
- Who is the assignee on this patent?
- Roche Diagnostics Operations Inc, Indiana Univ Research And Technology
- What technology area does this patent fall under?
- Primary CPC classification G01N33/56905. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Oct 09 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).