Multi-compartment device with magnetic particles

Patent metadata

Field	Value
Publication number	US-10092903-B2
Application number	US-80920808-A
Country	US
Kind code	B2
Filing date	Dec 16, 2008
Priority date	Dec 20, 2007
Publication date	Oct 9, 2018
Grant date	Oct 9, 2018

Abstract

The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

First claim

The invention claimed is:

1. A device for transferring magnetic particles in a fluidic sample, the device comprising:
first and second substrates forming, therebetween, two compartments and a channel interconnecting the two compartments; and
a valve-like structure that allows passage of the magnetic particles through the channel between the two compartments upon application of a magnetic force to the magnetic particles, wherein
the valve-like structure comprises a hydrophobic barrier formed by a silane hydrophobic surface in the channel that prevents a fluid disposed in one of the two compartments from migrating to the other of the two compartments in the absence of a magnetic force acting upon the magnetic particles.

2. The device according to claim 1 , wherein the magnetic force causes the magnetic particles to pass through from a first side of the hydrophobic barrier through to an opposing side of the hydrophobic barrier.

3. The device according to claim 2 , wherein the channel is a capillary channel.

4. The device according to claim 1 , wherein the compartments are in close proximity.

5. The device according to claim 1 , further comprising a magnetic source that is an electromagnet, an integrated current wire, a permanent magnet and a mechanically moving permanent magnet, or an electromagnet.

6. The device according to claim 1 , wherein:
the hydrophobic surfaces comprise opposed hydrophobic surfaces that provide the channel therebetween, and
the magnetic particles travel through the channel during the passage between the two compartments.

7. A device for transferring magnetic particles in a fluidic sample, the device comprising:
first and second substrates situated apart from each other and mirroring each other to form two compartments and a channel interconnecting the two compartments, one of the two compartments is configured to include the magnetic particles, and
a valve-like structure that allows passage of the magnetic particles through the channel between the two compartments upon application of a magnetic force to the magnetic particles, wherein
the valve-like structure comprises a hydrophobic barrier formed by a silane hydrophobic surface in the channel that prevents a fluid disposed in the one compartment from migrating to the other of the two compartments in the absence of the magnetic force acting upon the magnetic particles.

8. The device of claim 1 , wherein 50% or more of the channel comprises the hydrophobic surface.

9. The device of claim 1 , further comprising:
another valve-like structure comprising a silane hydrophobic barrier formed by a silane hydrophobic surface in another channel, wherein:
the first and second substrates form a third compartment that is interconnected to a first of the two compartments through the other channel,
the valve-like structure prevents a first fluid disposed in a second of the two compartments from migrating to the first compartment in the absence of the magnetic force acting upon the magnetic particles, and
the other valve-like structure prevents a second fluid disposed in the third compartment from migrating to the first compartment in the absence of another magnetic force acting upon other magnetic particles disposed within the third compartment.

10. The device of claim 1 , further comprising:
another valve-like structure comprising a silane hydrophobic barrier formed by a silane hydrophobic surface in another channel, wherein:
the first and second substrates form a third compartment that is interconnected to a first of the two compartments through the other channel,
the valve-like structure prevents a first fluid disposed in a second of the two compartments from migrating to the first compartment in the absence of the magnetic force acting upon the magnetic particles, and
the other valve-like structure prevents a second fluid disposed in the first compartment from migrating to the third compartment in the absence of another magnetic force acting upon other magnetic particles disposed within the first compartment.

11. The device of claim 10 , further comprising:
a third valve-like structure comprising a silane hydrophobic barrier formed by a silane hydrophobic surface in a third channel, wherein:
the first and second substrates form a fourth compartment that is interconnected to the first compartment through the third channel, and
the third valve-like structure prevents a third fluid disposed in the first compartment from migrating to the fourth compartment in the absence of a third magnetic force acting upon third magnetic particles disposed within the first compartment.

Assignees

• Prins Menno Willem Jose
• Maas Joost Hubert
• Immink Albert Hendrik Jan
• Van Dam Dirkjan Bernhard
• Koets Maatje
• Bruyninckx Michel J M
• Van Der Wijk Thea
• Boamfa Marius Iosif
• Den Dulk Remco
• Koninklijke Philips Nv

Inventors

• Prins Menno Willem Jose
• Maas Joost Hubert
• Immink Albert Hendrik Jan
• Van Dam Dirkjan Bernhard
• Koets Maatje
• Bruyninckx Michel J M
• Van Der Wijk Thea
• Boamfa Marius Iosif
• Den Dulk Remco

Classifications

• B01L2400/088

  by specific surface properties · CPC title

• B01L2300/161

  Control and use of surface tension forces, e.g. hydrophobic, hydrophilic · CPC title

• B01L2200/0647

  Handling flowable solids, e.g. microscopic beads, cells, particles · CPC title

• B01L3/502738 Primary

  characterised by integrated valves (throttle valves in microfluidic sample containers B01L3/502746) · CPC title

• B01L2400/0688

  surface tension valves, capillary stop, capillary break · CPC title