Blood filter and method for manufacturing the same

Patent metadata

Field	Value
Publication number	US-10092687-B2
Application number	US-201414896632-A
Country	US
Kind code	B2
Filing date	Jun 9, 2014
Priority date	Jun 7, 2013
Publication date	Oct 9, 2018
Grant date	Oct 9, 2018

Abstract

This is to provide a blood filter comprising a porous element; and a copolymer which exists in at least a part of a surface of the porous element, and which contains a recurring unit containing an organic group of the following formula (a) and a recurring unit containing an organic group of the following formula (b),
wherein U a1 , U a2 , U b1 , U b2 and U b3 , and An − are as defined in the present specification and the claims.

First claim

The invention claimed is:

1. A blood filter comprising
a porous element and
a coating that inhibits adhesion of biological substances, wherein the coating exists in at least a part of a surface of the porous element, and comprises a copolymer comprising (i) an ethylenically unsaturated monomer comprising the following formula (a) and (ii) an ethylenically unsaturated monomer comprising the following formula (b):

wherein U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion.

2. The blood filter according to claim 1 , wherein the ethylenically unsaturated monomers comprising the formulae (a) and (b) are derived from monomers of the following formulae (A) and (B), respectively:

wherein T a , T b , U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, Q a and Q b each independently represent a single bond, an ester bond or an amide bond, R a and R b each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom, An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion, and m is an integer of 0 to 6.

3. The blood filter according to claim 2 , wherein m is 1, and R a and R b each independently represent an ethylene group or a propylene group.

4. The blood filter according to claim 1 , wherein the copolymer further contains a crosslinked structure derived from a monomer of the following formula (C) or (D):

wherein T c , T d and U d each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, R c and R d each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom.

5. The blood filter according to claim 4 , wherein T c and T d each independently represent a hydrogen atom or a methyl group, U d represents a hydrogen atom, and R c and R d each independently represent an ethylene group or a propylene group.

6. The blood filter according to claim 1 , wherein the porous element is nonwoven fabric.

7. A method for manufacturing a blood filter of claim 1 , which method comprises
coating a copolymer comprising (i) an ethylenically unsaturated monomer comprising the following formula (a) and (ii) an ethylenically unsaturated monomer comprising the following formula (b):

wherein U a1 , U a2 , U b1 , U b2 , and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion

onto at least a part of a surface of a porous element, and
drying the coated porous element at −200° C. to 200° C.

8. The method according to claim 7 , wherein the ethylenically unsaturated monomers comprising the formulae (a) and (b) are derived from monomers of the following formulae (A) and (B), respectively:

wherein T a , T b , U a1 , U a2 , U b1 , U b2 and U b3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, Q a and Q b each independently represent a single bond, an ester bond or an amide bond, R a and R b each independently represent a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom, An − represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion, and m is an integer of 0 to 6.

9. The method according to claim 7 , wherein the coating is carried out by using a varnish containing the copolymer.

10. The method according to claim 9 , wherein the varnish containing a copolymer is previously adjusted a pH.

11. The method according to claim 7 , wherein the method further comprises washing the coated porous element before and/or after the drying of the coated porous element.

12. The method according to claim 11 , wherein the washing after the drying of the coated porous element is carried out by using at least one solvent selected from the group consisting of water and an aqueous solution containing an electrolyte.

Assignees

• Nissan Chemical Ind Ltd

Inventors

• Kanaki Tatsuro
• Kishioka Takahiro
• Nishino Taito
• Hiroi Yoshiomi
• Otani Ayako
• Ozawa Tomoyuki

Classifications

• A61M2202/0439

  White blood cells; Leucocytes · CPC title

• B01D71/82

  characterised by the presence of specified groups, e.g. introduced by chemical after-treatment · CPC title

• A61M1/3633 Primary

  Blood component filters, e.g. leukocyte filters · CPC title

• B01D39/1623

  of synthetic origin · CPC title

• B01D71/26

  Polyalkenes · CPC title