Antiviral composition containing material involved in phosphatidylcholine synthesis pathway

Patent metadata

Field	Value
Publication number	US-10092587-B2
Application number	US-201615389248-A
Country	US
Kind code	B2
Filing date	Dec 22, 2016
Priority date	Jun 25, 2014
Publication date	Oct 9, 2018
Grant date	Oct 9, 2018

Abstract

The present invention relates to an antiviral composition comprising any one selected from the group consisting of chlorine, phosphocholine, cytidine triphosphate, CDP-choline, phosphorylcholine, and phosphatidylcholine. The antiviral composition is harmless to the human body and exhibits an excellent inhibitory effect on virus proliferation. Therefore, it can be applied to a pharmaceutical composition for preventing or treating viral diseases as well as a health functional food, a quasi-drug composition, and a feed composition for preventing or ameliorating viral diseases.

First claim

The invention claimed is:

1. A method of enhancing antiviral activity in a subject infected by a virus, comprising administering an antiviral composition to the subject, wherein the virus belongs to the family picornaviridae and the composition comprises at least one substance involved in phosphatidyl synthesis pathway, selected from the following group:
i) choline;
ii) phosphocholine;
iii) cytidine diphosphate-choline (CDP-choline);
iv) phosphorylcholine; and
v) phosphatidylcholine.

2. The method of claim 1 , wherein the composition further comprises cytidine triphosphate (CTP).

3. The method of claim 1 , wherein the virus is any one selected from the group consisting of rhinovirus, enterovirus, cardiovirus, aphthovirus , and hepatovirus.

4. The method of claim 3 , wherein the rhinovirus is any one selected from the group consisting of rhinovirus type 2, type 3, and type 5.

5. The method of claim 3 , wherein the enterovirus is coxsackievirus type A or coxsackievirus type B.

6. A method for treating a subject infected by a viral disease, comprising administrating an antiviral composition to the subject, wherein the virus belongs to the family picornaviridae and the composition comprises at least one substance involved in phosphatidyl synthesis pathway, selected from the following group:
i) choline;
ii) phosphocholine;
iii) cytidine diphosphate-choline (CDP-choline);
iv) phosphorylcholine; and
v) phosphatidylcholine.

7. The method of claim 6 for treating a viral disease, wherein the viral disease comprises any one selected from the group consisting of cold, enteritis, hand-foot-mouth disease, viral meningitis, pneumonia, encephalitis, neurogenic pulmonary edema, conjunctivitis, encephalomyocarditis, myocarditis, hepatitis, poliomyelitis, paralysis, vesicular disease, myositis, pancreatitis, epidemic myalgia, herpangina, asthma, chronic obstructive pulmonary disease, sinusitis, and tympanitis.

8. The method of claim 6 for treating a viral disease, wherein the viral disease is a cold.

9. The method of claim 6 , wherein the composition further comprises cytidine triphosphate (CTP).

10. A method of enhancing antiviral activity in a subject, comprising administering an antiviral composition to the subject infected by a virus, wherein the virus is any one selected from the group consisting of rhinovirus type 2, rhinovirus type 3, rhinovirus type 5, coxsackievirus type A and coxsackievirus type B, and the composition comprises cytidine triphosphate (CTP).

Assignees

• Korea Res Inst Bioscience & Biotechnology

Inventors

• Kwon Dur Han
• Jang Mi Jin
• Song Jae Hyoung
• Enkhtaivan Gansukh
• Oh Sei Ryang

Classifications

• A23K20/26

  Compounds containing phosphorus · CPC title

• A23K20/163

  Sugars; Polysaccharides · CPC title

• A61K31/7068

  having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid · CPC title

• A61K31/706

  containing six-membered rings with nitrogen as a ring hetero atom · CPC title

• A61K9/0056

  Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals · CPC title