System for applying radiation to a target region within a subject

Patent metadata

Field	Value
Publication number	US-10092444-B2
Application number	US-201515121392-A
Country	US
Kind code	B2
Filing date	Feb 26, 2015
Priority date	Feb 27, 2014
Publication date	Oct 9, 2018
Grant date	Oct 9, 2018

Abstract

The invention relates to a system for applying radiation to a target region within a subject. An introduction element (12) like a brachytherapy catheter is inserted into the subject and a radiation source (10) is moved within the introduction element such that it is located within or close to the target region. The target region is heated, wherein the movement of the radiation source within the introduction element is controlled depending on the temperature along the introduction element. The susceptibility of the subject for the radiation emitted by the radiation source at a respective location along the length of the introduction element can depend on the temperature at the respective location such that by controlling the movement of the radiation source depending on the temperature along the length of the introduction element the application of the radiation can be optimized.

First claim

The invention claimed is:

1. A system for applying radiation to a target region within a subject, wherein the system comprises:
an elongated introduction element for being inserted into the subject and for introducing a radiation source emitting radiation to be applied to the target region into the subject,
a moving unit for moving the radiation source within the introduction element such that the radiation source is located within or close to the target region,
a heating unit for heating the target region,
a temperature determination unit for determining the temperature along the length of the introduction element, and
a control unit for controlling the moving unit depending on the determined temperature.

2. The system as defined in claim 1 , wherein the control unit is adapted to control the moving unit such that the radiation source is moved to and stopped at a location within the subject, at which the determined temperature is larger than a predefined threshold temperature.

3. The system as defined in claim 1 , wherein the system further comprises a target region providing unit for providing the position of the target region within the subject, wherein the temperature determination unit is adapted to determine a temperature within the target region based on the temperature determined along the length of the introduction element and the provided target region and wherein the control unit is adapted to control the moving unit such that the radiation source is not introduced into the subject or retracted from the subject, if the temperature within the target region is below a predefined threshold temperature.

4. The system as defined in claim 1 , wherein the system further comprises a target region providing unit for providing the position of the target region within the subject, wherein the temperature determination unit is adapted to determine a temperature within the target region based on the temperature determined along the length of the introduction element and the provided target region, wherein the system further comprises an output unit for outputting an alarm, if the temperature within the target region is below a predefined threshold.

5. The system as defined in claim 1 , wherein the system further comprises a target region providing unit for providing the position of the target region within the subject and a plan generation unit for generating a plan defining dwell positions and dwell times of the radiation source within the subject based on the provided position of the target region within the subject and the determined temperature, wherein the control unit is adapted to control the moving unit in accordance with the generated plan.

6. The system as defined in claim 5 , wherein the plan generation unit is adapted to generate the plan such that it defines dwell positions only at locations within the subject, at which the determined temperature is larger than a predefined threshold temperature.

7. The system as defined in claim 5 , wherein the plan generation unit is adapted to generate the plan such that a dwell time at a dwell position depends on the temperature at the dwell position.

8. The system as defined in claim 1 , wherein the introduction element comprises an optical fiber) arranged along the length of the introduction element for generating optical signals, which are indicative of the temperature along the length of the introduction element and wherein the temperature determination unit is adapted to determine the temperature along the length of the introduction element based on the generated optical signals.

9. The system as defined in claim 8 , wherein the system further comprises a position determination unit for determining the position of the introduction element based on the optical signals.

10. The system as defined in claim 8 , wherein the system comprises an image providing unit for providing an image of the subject showing at least the target region, wherein the temperature determination unit is adapted to determine a first temperature along the length of the introduction element based on the optical signals and to determine a second temperature based on the provided image by using an image-to-temperature transformation process, wherein the image-to-temperature transformation process is calibrated by using the first temperature.

11. The system as defined in claim 1 , wherein the system further comprises a position determination unit for determining the position of the introduction element, a target region providing unit for providing the position of the target region within the subject and a plan generation unit for generating a plan defining dwell positions and dwell times of the radiation source within the subject based on the provided position of the target region within the subject, the determined temperature and the determined position of the introduction element, wherein the control unit is adapted to control the moving unit in accordance with the generated plan.

12. The system as defined in claim 1 , wherein the system further comprises a position determination unit for determining the position of the introduction element, an image providing unit for providing an image of the subject showing at least the target region and an output unit comprising a display for displaying the image overlaid with a representation of the introduction element based on the determined position of the introduction element.

13. The system as defined in claim 1 , wherein the system further comprises a control unit for controlling the heating unit depending on the determined temperature.

14. A method for applying radiation to a target region within a subject, wherein the method comprises:
heating the target region by using a heating unit,
determining a temperature along a length of an elongated introduction element, which has been inserted into the subject for introducing a radiation source emitting radiation to be applied to the target region into the subject, by a temperature determination unit, and
controlling a moving unit for moving the radiation source within the introduction element such that the radiation source is located within, adjacent or surrounding the target region depending on the determined temperature by a control unit.

15. A non-transitory computer-readable storage medium in which computer-executable code is stored, the computer executable code configured to cause a computing device in which the non-transitory computer-readable storage medium is loaded to cause the system of claim 1 to perform the acts of:
inserting an elongated introduction element into a subject and introducing a radiation source emitting radiation to be applied to the target region into the subject,
causing a moving unit to move a radiation source within the introduction element such that the radiation source is located within, adjacent or surrounding a target region,
causing a heating unit to heat the target region,
determining the temperature along the length of the introduction element using a temperature determination unit, and
causing a control unit to move the moving unit depending on the determined temperature.

Assignees

• Koninklijke Philips Nv

Inventors

• Hautvast Guillaume Leopold Theodorus Frederik
• Binnekamp Dirk

Classifications

• A61B18/14

  Probes or electrodes therefor · CPC title

• A61B2034/2061

  using shape-sensors, e.g. fiber shape sensors with Bragg gratings · CPC title

• A61N5/1071

  for verifying the dose delivered by the treatment plan · CPC title

• A61N5/1001

  using radiation sources introduced into or applied onto the body; brachytherapy · CPC title

• A61B2017/3413

  guided by ultrasound · CPC title