Silent multi-gradient echo magnetic resonance imaging

Patent metadata

Field	Value
Publication number	US-10088539-B2
Application number	US-201615142957-A
Country	US
Kind code	B2
Filing date	Apr 29, 2016
Priority date	Apr 22, 2016
Publication date	Oct 2, 2018
Grant date	Oct 2, 2018

Abstract

Methods and systems for production of silent, multi-gradient-echo, magnetic resonance images are provided. The methods employ iterative application of small updates to the magnetic field gradient followed by a short, non-selective radiofrequency pulse excitation and for free induction decay data acquisition. The magnetic field gradient updates allow for silent, self-refocusing pulse sequence. Subsequent applications of the magnetic field gradients allow for multiple echo data acquisitions, which may allow fast, silent production of T2*-weighted images.

First claim

The invention claimed is:

1. A magnetic resonance imaging method, comprising:
acquiring a free induction decay (FID) dataset from a subject using a magnetic resonance imaging system, wherein the FID dataset is obtained by performing a free induction decay (FID) acquisition process over iterations, each iteration corresponding to a k-space spoke of a sequence of k-space spokes, and wherein an iteration of the FID acquisition process comprises:
updating a magnetic field gradient based on a k-space spoke of the sequence of k-space spokes corresponding to the iteration of the FID acquisition process;
applying a radiofrequency excitation pulse while preserving the magnetic field gradient to encode the k-space spoke corresponding to the iteration of the FID acquisition process; and
acquiring a first dataset corresponding to the k-space spoke corresponding to the iteration of the FID acquisition process, wherein the first dataset is at least a portion of the FID dataset; and
wherein an interconnection of the k-space spokes of the sequence of k-space spokes forms a closed k-space trajectory that refocuses FID signals resulting from the application of the radiofrequency excitation pulse of an initial iteration of the FID acquisition process.

2. The method of claim 1 , comprising acquiring at least a portion of a gradient echo dataset from the subject over the same sequence and the same order of k-space spokes as the FID acquisition process using the magnetic resonance imaging system, wherein the portion of the gradient echo dataset is obtained by performing a gradient echo acquisition process by repeating the iterations of the FID acquisition process but without applying radiofrequency excitation.

3. The method of claim 2 , wherein the gradient echo acquisition process follows immediately the FID acquisition process, and wherein the gradient echo dataset obtained in the gradient echo acquisition process comprises a gradient echo data corresponding to a refocused portion of the FID dataset obtained during the corresponding iteration of the FID acquisition process.

4. The method of claim 2 , wherein the magnetic field gradient is updated concurrently with the acquisition of data during the FID acquisition process and the gradient echo acquisition process such that at least one k-space spoke of the sequence of k-space spokes is curved.

5. The method of claim 2 , wherein a magnitude of the magnetic field gradient is substantially constant at least throughout the multiple iterations of the FID acquisition process and the gradient echo acquisition process.

6. The method of claim 2 , comprising reconstructing a complex image of the subject from at least the FID dataset or the gradient echo dataset.

7. The method of claim 2 , comprising reconstructing a proton density map, a T2*map, an R2* map, a ΔB 0 map, or a susceptibility map, or any combination thereof, of the subject from at least the FID dataset, the gradient echo dataset a subsequent gradient dataset, or any combination thereof.

8. The method of claim 2 , comprising sorting acquired data according to echo time into at least the FID dataset and the gradient echo dataset.

9. The method of claim 2 , comprising performing spectroscopic imaging by obtaining chemical shift maps via Fourier analysis of the obtained FID and gradient echo datasets.

10. The method of claim 2 , wherein the gradient echo dataset obtained during the gradient echo acquisition process includes a mixture of echo-out signals and echo-in signals, and wherein the echo-out and echo-in signals are separated with low-pass filtering and high-pass filtering or phase cycling, and wherein the separated echo-out and echo-in signals are combined to produce a combined echo-in/echo-out dataset.

11. The method of claim 1 , wherein the k-space spokes of the sequence of k-space spokes are in the same plane of a frequency space.

12. The method of claim 1 , wherein the step of acquiring the first dataset begins immediately after the application of the non-selective radiofrequency excitation pulse such that the magnetic resonance imaging method is a zero-TE imaging method.

13. The method of claim 1 , comprising applying a preparatory pulse sequence before the iteration of the FID acquisition process.

14. The method of claim 1 , comprising acquiring two or more gradient echo datasets from the subject over the same sequence and the same order of k-space spokes as the FID acquisition process using the magnetic resonance imaging system, wherein the two or more gradient echo datasets are obtained by performing two or more respective gradient echo acquisition processes which each repeat the iterations of the FID acquisition process without applying radiofrequency excitation, and wherein the two or more respective gradient echo acquisition processes are performed sequentially.

15. A non-transitory computer-readable memory device comprising instructions for a magnetic resonance imaging system, the instructions comprising:
causing gradient coils of the magnetic resonance imaging system to apply a sequence of magnetic field gradients over time to a subject, each magnetic field gradient of the sequence of magnetic field gradients corresponding to a k-space spoke of a sequence of k-space spokes;
causing a radiofrequency excitation coil of the magnetic resonance imaging system to apply a radiofrequency excitation pulse to the subject while each magnetic field gradient of the sequence of magnetic field gradients is applied; and
causing acquisition coils of the magnetic resonance imaging system to collect a free induction decay (FID) dataset corresponding to radiofrequency emissions from the subject immediately following each radiofrequency excitation pulse; and
wherein an interconnection of the k-space spokes of the sequence of k-space spokes forms a closed k-space trajectory that refocuses FID signals resulting from the application of the radiofrequency excitation pulses corresponding to the sequence of magnetic field gradients.

16. The memory device of claim 15 , wherein the instructions comprise:
causing the gradient coils of the magnetic resonance imaging system to apply the sequence of magnetic field gradients over time to the subject; and
causing the acquisition coils of the magnetic resonance imaging system to collect one or more gradient echo datasets corresponding to echoes of the radiofrequency emissions from the subject following the radiofrequency excitation.

17. The memory device of claim 16 , wherein the instructions comprise generating a complex image from the FID dataset, at least one of the one or more gradient echo datasets, or any combination thereof.

18. The memory device of claim 17 , wherein the instructions comprise generating a proton density map, a T2* map, an R2* map, a ΔB 0 map, a susceptibility map, or any combination thereof, of the subject from the FID dataset, at least one of the one or more gradient echo datasets, or any combination thereof.

19. A magnetic resonance imaging system comprising:
a scanner comprising gradient coils, a radiofrequency coil, and acquisition coils; and
control circuitry configured to cause the scanner to:
cause the gradient coils to apply a sequence of magnetic field gradients over time to a subject, each magnetic field gradient of the sequence of magnetic field gradients corresponding to a k-space spoke of a sequence of k-space spokes, wherein an interconnection of the k-space spokes of the sequence of k-space spokes forms a closed k-space trajectory;
cause a radiofrequency excitation coil of the ma

Assignees

• Gen Electric

Inventors

• Wiesinger Florian
• Menini Anne
• Solana Sanchez Ana Beatriz

Classifications

• G01R33/5616

  using gradient refocusing, e.g. EPI · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/4818 Primary

  MR characterised by data acquisition along a specific k-space trajectory or by the temporal order of k-space coverage, e.g. centric or segmented coverage of k-space · CPC title

• G01R33/4816 Primary

  NMR imaging of samples with ultrashort relaxation times such as solid samples, e.g. MRI using ultrashort TE [UTE], single point imaging, constant time imaging · CPC title

• G01R33/3854 Primary

  means for active and/or passive vibration damping or acoustical noise suppression in gradient magnet coil systems · CPC title