Silicone hydrogel, medical device, lens for eye and contact lens

Patent metadata

Field	Value
Publication number	US-10087274-B2
Application number	US-201515321516-A
Country	US
Kind code	B2
Filing date	Jun 16, 2015
Priority date	Jun 27, 2014
Publication date	Oct 2, 2018
Grant date	Oct 2, 2018

Abstract

In order to provide a silicone hydrogel which has high uniformity in polymerization rates of polymerization components used for copolymerization, excellent mechanical characteristics, excellent optical characteristics and good shape recoverability and in order to also provide various medical devices and ocular lenses having an excellent balance among elasticity, wettability and transparency, the present invention provides a silicone hydrogel which has a repeating unit derived from a monofunctional linear silicone (meth)acrylate and a repeating unit derived from a hydrophilic (meth)acrylate, and wherein the content of the repeating units derived from (meth)acrylates is more than 80% by mass.

First claim

The invention claimed is:

1. A silicone hydrogel comprising a repeating unit derived from a monofunctional linear silicone (meth)acrylate and a repeating unit derived from a hydrophilic (meth)acrylate wherein
the content of the repeating units derived from the (meth)acrylates is more than 80% by mass; and
the ratio of a repeating unit derived from a hydrophilic (meth)acrvlate having no hydroxyl group in the repeating units as a fraction of the total amount of hydrophilic (meth)acrylates is 20% by mass or more.

2. The silicone hydrogel according to claim 1 , wherein the monofunctional linear silicone (meth)acrylate is represented by the following general formula (a):

wherein R 1 represents hydrogen or a methyl group; R 2 represents an optionally substituted divalent organic group having 1 to 20 carbon atoms; R 3 to R 6 each independently represent an optionally substituted alkyl group having 1 to 20 carbon atoms or an optionally substituted aryl group having 6 to 20 carbon atoms; R 7 represents an optionally substituted alkyl group having 1 to 20 carbon atoms or an optionally substituted aryl group having 6 to 20 carbon atoms; and n represents an integer of 1 to 200 which optionally has distribution.

3. The silicone hydrogel according to claim 1 , further comprising a repeating unit derived from a monofunctional silicone (meth) acrylate different from the monofunctional linear silicone (meth)acrylate.

4. The silicone hydrogel according to claim 1 , wherein the content of the repeating unit derived from the silicone (meth)acrylate is 30 to 95% by mass.

5. A silicone hydrogel comprising a repeating unit derived from a monofunctional linear silicone (meth)acrylate and a repeating unit derived from a hydrophilic (meth)acrylate, wherein
the content of the repeating units derived from the (meth)acrylates is more than 80% by mass; the hydrophilic (meth)acrylate has a group selected from the group consisting of a hydroxyl group, an alkoxy group, a carboxy group and a sulfonic acid group in the molecule; and
the hydrophilic (meth)acrylate is represented by the following general formula (c): [Chemical Formula 2]
wherein R 8 represents hydrogen or a methyl group; R 9 to R 12 each independently represent hydrogen, an optionally substituted alkyl group having 1 to 20 carbon atoms, or an optionally substituted aryl group having 6 to 20 carbon atoms; R 13 represents hydrogen, an optionally substituted alkyl group having 1 to 20 carbon atoms, or an optionally substituted aryl group haying 6 to 20 carbon atoms; and m represents an integer of 2 to 100 which optionally has distribution.

6. The silicone hydrogel according to claim 1 , wherein the content of the repeating unit derived from the hydrophilic (meth)acrylate is 5 to 70% by mass.

7. The silicone hydrogel according to claim 1 , comprising a repeating unit derived from a polyfunctional (meth)acrylate.

8. The silicone hydrogel according to claim 7 , wherein the content of the repeating unit derived from the polyfunctional (meth)acrylate is 0.05 to 10% by mass.

9. A medical device which is produced using the silicone hydrogel according to claim 1 .

10. The medical device according to claim 9 , wherein the medical device is a lens for eye.

11. The medical device according to claim 10 , wherein the lens for eye is a contact lens.

Assignees

• Toray Industries

Inventors

• Kato Tomohiro
• Fujisawa Kazuhiko
• Nakamura Masataka

Classifications

• C08F230/08 Primary

  containing silicon · CPC title

• G02B1/043

  Contact lenses · CPC title

• A61L27/18

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08F20/26

  Esters containing oxygen in addition to the carboxy oxygen · CPC title

• A61L2430/16

  for reconstruction of eye parts, e.g. intraocular lens, cornea · CPC title