Absorbable medical devices based on novel films and foams made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics

Patent metadata

Field	Value
Publication number	US-10086109-B2
Application number	US-201514728177-A
Country	US
Kind code	B2
Filing date	Jun 2, 2015
Priority date	Jun 2, 2015
Publication date	Oct 2, 2018
Grant date	Oct 2, 2018

Abstract

Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.

First claim

We claim:

1. An absorbable foam, comprising a semi crystalline absorbable segmented copolymer, said copolymer comprising repeating units of polymerized lactide and polymerized epsilon-caprolactone, wherein the mole ratio of polymerized lactide to polymerized epsilon-caprolactone is between about 60:40 to about 75:25, said copolymer having a first heat Tg, as determined by differential scanning calorimetry at a scan rate of 10° C. per minute, equal to or less than 0° C., and a crystallinity level of about 20 percent to about 50 percent, as measured by wide angle X-ray diffraction, wherein the foam is made from a lyophilization solution having a solid content of between about 10 weight percent and 20 weight percent, and wherein the foam has a mechanical integrity at least 64 days post-implantation or having mechanical integrity after at least 64 days of incubation in a buffer of pH 7.27 at 37° C.

2. The foam of claim 1 having a thickness between about 40 mils and about 200 mils.

3. The foam of claim 1 , having a crystallinity level of about 25 percent to about 50 percent.

4. The foam of claim 1 , wherein the copolymer has an inherent viscosity at least about 0.5 dL/g, as measured in a 0.1 g/dl solution of HFIP at 25° C.

Assignees

• Ethicon Inc

Inventors

• Andjelic Sasa
• Jamiolkowski Dennis D
• Donners Jackie
• Timmer Mark

Classifications

• C08L67/04

  Polyesters derived from hydroxycarboxylic acids, e.g. lactones (C08L67/06 takes precedence) · CPC title

• C08J2367/04

  Polyesters derived from hydroxy carboxylic acids, e.g. lactones (C08J2367/06 takes precedence) · CPC title

• C08J2300/16

  Biodegradable polymers · CPC title

• C08J2205/02

  the finished foam itself being a gel or a gel being temporarily formed when processing the foamable composition · CPC title

• C08J2201/0482

  the liquid phase being organic · CPC title