Reagent store

Patent metadata

Field	Value
Publication number	US-10081503-B2
Application number	US-201514733543-A
Country	US
Kind code	B2
Filing date	Jun 8, 2015
Priority date	Nov 22, 2010
Publication date	Sep 25, 2018
Grant date	Sep 25, 2018

Abstract

An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.

First claim

What is claimed:

1. A method of providing reagent cassettes to an analytical system comprising:
(i) a closed reagent store and (ii) a temporary store, each of (i) and (ii) comprising (x) a loading interface adapted to receive one or more reagent cassettes, (y) an internal storage and retrieval system including an elevator having a Y-handler and an X-axis, and (z) an identification unit configured to read and write information to and from an RFID tag positioned on said reagent cassette and thereby identify said reagent cassette, wherein said information comprises an on-board time stamp; and
(iii) a transport system comprising an additional handler, wherein said transport system is configured for bidirectional transport of said reagent cassette between one or more of said reagent store, said temporary store, and one or more stations of said analytical system;
wherein said analytical system is operably connected to a control unit configured to determine a cumulated on-board time of a reagent cassette in said temporary store, and one or more of said stations of said analytical system and transfer instructions to one or more of said reagent store and said temporary store regarding reagent cassette requirements for said analytical system;
the method comprising the steps of:
a) loading a plurality of reagent cassettes into said loading interface;
b) identifying said reagent cassettes using said identification unit;
c) positioning, automatically, said reagent cassettes in said reagent store by said elevator;
d) transferring said instructions from said control unit to said reagent store;
e) removing a reagent cassette from said reagent store using said additional handler and triggering the identification unit to write to said RFID an on-board time stamp to said RFID which corresponds to the time the reagent cassette is removed from said reagent store;
f) transporting said reagent cassette with said additional handler to a station of said analytical system;
g) comparing said on-board time stamp to an actual time to calculate a cumulated on-board time; and
h) returning said reagent cassette to one of said reagent store and said temporary store if the cumulated on-board time is less than a preset value and transferring said reagent cassette to a waste station when the cumulated on-board time exceeds said preset value,
wherein steps b) to i) are automated.

2. The method according to claim 1 , wherein said reagent store is cooled by an active cooling unit.

3. The method of claim 1 , wherein step f) comprises transporting said reagent cassette to a station comprising a pipetting device.

4. The method of claim 1 , wherein step h) comprises returning said reagent cassette to said reagent store for long term storage.

5. The method of claim 1 , wherein said preset value is dependent on a temperature in one or more of said temporary store and said station of said analytical system.

Assignees

• Roche Molecular Systems Inc

Inventors

• Frank Paul
• Gisler Andreas
• Huesler Robert
• Knobel Rolf
• Rinderknecht Markus

Classifications

• G01N35/1002 Primary

  Reagent dispensers · CPC title

• G01N2035/00811

  consumable or exchangeable components other than sample carriers, e.g. detectors, flow cells · CPC title

• B65G2814/0302

  Central control devices · CPC title

• G01N2035/1051

  for transporting containers, e.g. retained by friction · CPC title

• G01N35/00732

  Identification of carriers, materials or components in automatic analysers · CPC title