Mucosal dose control radiotherapy apparatus using magnetic fields

Patent metadata

Field	Value
Publication number	US-10080912-B2
Application number	US-201514976945-A
Country	US
Kind code	B2
Filing date	Dec 21, 2015
Priority date	Dec 23, 2014
Publication date	Sep 25, 2018
Grant date	Sep 25, 2018

Abstract

A mucosal dose control radiotherapy apparatus using magnetic fields includes: a radiation generator irradiating radiation toward a tumor region of a patient; a magnetic field generator forming a magnetic field in a body of the patient; and a controller controlling a radiation dose transmitted from the radiation generator to the tumor region of the patient by adjusting a direction and a strength of the magnetic field of the magnetic field generator.

First claim

What is claimed is:

1. A mucosal dose control radiotherapy apparatus using magnetic fields comprising:
a radiation generator configured to irradiate photon radiation, by passing through a body cavity of a patient and mucosa of the body cavity, toward a tumor region existing at a distance from under the mucosa of the body cavity of the patient;
a magnetic field generator configured to form a magnetic field in a body of the patient; and
a controller configured to control a radiation dose transmitted from the radiation generator to the tumor region of the patient by adjusting a direction and strength of the magnetic field of the magnetic field generator,
wherein the magnetic field generator is configured to form the magnetic field having a component perpendicular to a direction of the irradiated photon radiation, and
wherein the controller is configured to control the magnetic field so that,
at the body cavity, a secondary electron emitted from the irradiated photon radiation is dispersed into the body cavity by a Lorentz's force of the magnetic field, and
at the tumor region, a secondary electron emitted from the irradiated photon radiation passed through the body cavity is provided to the tumor region.

2. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the magnetic field generator forms a uniform or non-uniform magnetic field area in all regions or a peripheral region of the body of the patient to which the photon radiation is irradiated by the radiation generator.

3. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the controller further comprises a calculator calculating a radiation dose that is transmitted to the tumor region of the patient through the magnetic field.

4. The mucosal dose control radiotherapy apparatus of claim 3 , wherein the calculator is configured to calculate radiation dose absorbed at the predetermined position of the body based on a Full Monte Carlo Simulation Method having a toolkit capable of simulating a magnetic field.

5. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the magnetic field generator comprises one of an electromagnet, a permanent magnet, and a combination thereof.

6. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the magnetic field generator rotates around the patient or is disposed in a fixed or movable manner around the patient.

7. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the apparatus is configured to interwork with a positioning system using an image, and used in position correction of the patient and position correction of the magnetic field generator.

8. The mucosal dose control radiotherapy apparatus of claim 1 ,
wherein the apparatus has a degree of freedom that optimizes a dose by the magnetic field of the patient using a body-insertable prosthesis or a prosthesis having a balloon shape including a prosthesis material therein.

9. The mucosal dose control radiotherapy apparatus of claim 8 , wherein the prosthesis is inserted along with adding a material favorable for imaging to verify and correct a state of the prosthesis using an image as well as for conversion of a shape of the mucosa or for conversion of a component to optimize the dose.

10. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the controller is configured to control the magnetic field generator to deflect the secondary electron into the magnetic field in order to reduce a damage to a normal tissue in the body of the patient.

11. The mucosal dose control radiotherapy apparatus of claim 1 , wherein the magnetic field is formed in an area between the radiation generator and the tumor region, the area including the body cavity.

12. A mucosal dose control radiotherapy apparatus using magnetic fields comprising:
a radiation generator configured to irradiate photon radiation toward a tumor region of a patient
a magnetic field generator configured to form a magnetic field in a body of the patient
a controller configured to control a radiation dose transmitted from the radiation generator to the tumor region of the patient by adjusting a direction and a strength of the magnetic field of the magnetic field generator; and
a calculator calculating a radiation dose that is transmitted to the tumor region of the patient through the magnetic field
wherein the controller is configured to control, by using the magnetic field, a secondary electron emitted from the irradiated photon radiation, in order to control the radiation dose,
wherein the calculator calculates the radiation dose that is transmitted to the tumor region of the patient based on the following equation 1
D ( x,y,z )=∫∫∫( TERMA ( x′,y′,z′ )×Kernel( x,x′,y,y′,z,z′ ) dx′dy′dz′   [Equation 1]

 where
D(x,y,z) denotes a radiation dose transmitted to the tumor region of the patient,
TERMA(x′, y′, z′) denotes a total energy of an incident radiation beam that is reduced in a micro volume dx′dy′dz′, and
Kernel(x,x′,y,y′,z,z′) denotes a dose ratio of a unit energy that is reduced in a micro volume dx′dy′dz′ being absorbed at a predetermined position (x,y,z), and

wherein the Kernel(x,x′,y,y′,z,z′) is obtained by using the magnetic field of the magnetic field generator.

Assignees

• Asan Found

Inventors

• Kwak Jung Won
• Jung Nuri Hyun
• Yoon Kyoung Jun
• Cho Byoung Chul
• Ahn Seung Do
• Lee Sang Wook

Classifications

• A61N5/1067

  in real time, i.e. during treatment · CPC title

• A61N2/06

  using magnetic fields produced by permanent magnets (A61N2/12 takes precedence) · CPC title

• A61N2005/1089

  Electrons · CPC title

• A61N5/1048

  Monitoring, verifying, controlling systems and methods · CPC title

• A61N5/1043 Primary

  Scanning the radiation beam, e.g. spot scanning or raster scanning · CPC title