Methods of treating pruritus

Patent metadata

Field	Value
Publication number	US-10080759-B2
Application number	US-201515109164-A
Country	US
Kind code	B2
Filing date	Jan 21, 2015
Priority date	Jan 22, 2014
Publication date	Sep 25, 2018
Grant date	Sep 25, 2018

Abstract

A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.

First claim

That which is claimed is:

1. A method of treating pruritus in skin of a subject in need thereof, comprising administering to said subject an active agent in a treatment effective amount to treat pruritus in said skin of said subject,
wherein said administering comprises topically administering to said skin of said subject a composition comprising said active agent in an amount of 0.01% to 1% by weight of said composition, and
wherein said active agent is a compound having a structure represented by:

wherein:
each R is independently C 1-12 alkyl or —(CH 2 ) m CH 2 OX;
m is 1 or 2;
X is C 1-12 alkyl;
each A is an independently selected hydrogen, halogen, —NO 2 , or —CHO;
M is manganese, iron, copper, cobalt, nickel or zinc; and
Z − is a counterion;

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein said subject is afflicted with dermal or pruritoceptive itch.

3. The method of claim 1 , wherein said subject is afflicted with neuropathic itch.

4. The method of claim 1 , wherein said subject is afflicted with neurogenic itch.

5. The method of claim 1 , wherein said subject is afflicted with psychogenic itch.

6. The method of claim 1 , wherein said active agent has a structure represented by:

wherein:
each R is C 1-12 alkyl;
each A is, independently, hydrogen, halogen, —NO 2 or —CHO;
M is metal selected from the group consisting of manganese, iron, copper, cobalt, nickel and zinc, and
Z − is a counterion.

7. The method of claim 1 , wherein said active agent has the structure:

wherein Z − is a counterion.

8. The method of claim 1 , wherein said active agent has a structure represented by:

wherein:
each R is —(CH 2 ) m CH 2 OX;
m is 1 or 2;
X is C 1-12 alkyl;
each A is, independently, hydrogen, halogen, —NO 2 or —CHO;
M is metal selected from the group consisting of manganese, iron, copper, cobalt, nickel and zinc, and
Z − is a counterion.

9. The method of claim 1 , wherein said active agent has the structure:

wherein Z − is a counterion.

10. The method of claim 1 , wherein said composition comprises said active agent in an amount of 0.01% to 0.1% by weight of said composition.

11. The method of claim 1 , wherein said administering relieves pruritus in said skin of said subject within 30 minutes of administering said active agent to said skin.

12. The method of claim 1 , wherein said administering reduces frequency of scratching a region of said skin within 30 minutes of administering said active agent to said skin.

13. The method of claim 1 , wherein said administering reduces urge to scratch a region of said skin within 30 minutes of administering said active agent to said skin.

14. The method of claim 1 , wherein said administering relieves pruritus in said skin of said subject within 15 minutes of administering said active agent to said skin.

15. The method of claim 1 , wherein said administering relieves pruritus in said skin of said subject for up to 12 hours after administering said active agent to said skin.

Assignees

• Univ Duke
• Biomimetix Jv Llc
• Biomimetix J V Llc

Inventors

• Ji Ru-Rong
• Liu Tong
• Batinic-Haberle Ines
• Warner David S
• Stone Kimberly C
• Crapo James D

Classifications

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K31/4188

  condensed with other heterocyclic ring systems, e.g. biotin, sorbinil · CPC title

• A61K31/555 Primary

  containing heavy metals, e.g. hemin, hematin, melarsoprol · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61P17/04

  Antipruritics · CPC title