Methods, devices, and systems for treating pericardial tissue

Patent metadata

Field	Value
Publication number	US-10080650-B2
Application number	US-201615014364-A
Country	US
Kind code	B2
Filing date	Feb 3, 2016
Priority date	Feb 3, 2015
Publication date	Sep 25, 2018
Grant date	Sep 25, 2018

Abstract

A method of treating pericardial tissue that includes contacting at least a portion of a pericardial sac with a chemical while the pericardial sac is tensioned by an application of fluid pressure to an inside face of the pericardial sac.

First claim

What is claimed is:

1. A method of treating pericardial tissue comprising:
securing a base of a pericardial sac to a vessel, the vessel comprising a side wall having a first vessel rim and a second vessel rim;
contacting at least a portion of the pericardial sac with a chemical while the pericardial sac is tensioned by an application of fluid pressure to an inside face of the pericardial sac;
wherein the first vessel rim is adapted to mate with a lid to form an enclosure; and
wherein the base of the pericardial sac is secured between the second vessel rim and a locking collar.

2. The method of claim 1 , wherein the pericardial sac is tensioned by delivering the chemical to the inside face.

3. The method of claim 1 , wherein in the chemical is in an aqueous solution.

4. The method of claim 1 , wherein the chemical comprises glutaraldehyde.

5. The method of claim 1 , wherein the second vessel rim has a diameter within plus or minus 20% of the diameter of the base of the pericardial sac.

6. The method of claim 1 , wherein the vessel comprises at least one inlet or outlet adapted to supply at least one fluid to the inside face of the pericardial sac or evacuate a fluid from an outside face of the pericardial sac.

7. The method of claim 1 , wherein at least a portion of the pericardial sac is in contact with the chemical for at least 30 minutes.

8. The method of claim 7 , wherein the fluid pressure applied to the inside face of the pericardial sac is varied during contact with the chemical.

9. The method of claim 1 , wherein the inside face is pressurized to a pressure of at least 0.4 atmospheres.

10. The method of claim 1 , wherein the inside face is pressurized up to a pressure of 3 atmospheres.

11. The method of claim 1 , wherein the inside face is treated with a first chemical solution and an outside face is treated with a second chemical solution that is different from the first chemical solution.

12. The method of claim 1 , wherein the inside face is treated with a chemical while the inside face is pressurized at a first pressure and an outside face is treated with a chemical while the inside face is pressurized at a second pressure that is different from the first pressure.

13. The method of claim 1 , wherein the inside face is pressurized to a pulsed pressure, the pulsed pressure being applied to the inside face between 1 to 20 times per minute.

14. An apparatus for treating pericardial tissue comprising:
a vessel comprising a side wall, the side wall comprising a first vessel rim and a second vessel rim, the vessel having at least one vessel inlet or vessel outlet;
a lid having a lid rim adapted to mate with the first vessel rim to form an enclosure, the lid comprising at least one lid inlet or lid outlet, and
a locking collar;
wherein the vessel is adapted to secure a base of a pericardial sac between the second vessel rim and the locking collar and to pressurize an inside face of the pericardial sac.

15. The apparatus of claim 14 , further comprising a controller configured to supply fluids and chemicals to the at least one vessel inlet or vessel outlet and the at least one lid inlet or lid outlet to treat a pericardial sac retained between the second vessel rim and the locking collar.

16. The apparatus of claim 14 , further comprising a pressure gauge coupled to one of the vessel and the lid to detect a pressure within the vessel.

17. An apparatus for treating pericardial tissue comprising:
a vessel comprising a side wall, the side wall comprising a first vessel rim and a second vessel rim, the vessel having at least one vessel inlet or vessel outlet;
a lid having a lid rim adapted to mate with the first vessel rim to form an enclosure, the lid comprising at least one lid inlet or lid outlet, and
a locking collar;
wherein the vessel is adapted to secure a base of a pericardial sac between the second vessel rim and the locking collar and to deliver chemical solutions through the first vessel rim to an inside face of the pericardial sac.

Assignees

• Boston Scient Scimed Inc

Inventors

• Mccarthy Ray

Classifications

• A61L27/367

  Muscle tissue, e.g. sphincter · CPC title

• A61L27/3691

  characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation · CPC title

• A61F2/2415 Primary

  Manufacturing methods · CPC title

• A61L27/3645

  Connective tissue · CPC title

• A61L2430/40

  Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking · CPC title