Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof
US-9689872-B2 · Jun 27, 2017 · US
Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof
US10078088B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10078088-B2 |
| Application number | US-201715816505-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 17, 2017 |
| Priority date | Jul 16, 2010 |
| Publication date | Sep 18, 2018 |
| Grant date | Sep 18, 2018 |
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Abstract
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The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
First claim
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What is claimed is: 1. A polypeptide comprising an amino acid sequence that consists of 4 framework regions (FR1 to FR4, respectively) and 3 complementary determining regions (CDR1 to CDR3, respectively) according to the formula: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, wherein CDR1 is the amino acid sequence of SEQ ID NO:30 or an amino acid sequence that has at least 80% identity with SEQ ID NO:30, wherein CDR2 is the amino acid sequence of SEQ ID NO:43 or an amino acid sequence that has at least 80% identity with SEQ ID NO:43, wherein CDR3 is the amino acid sequence of SEQ ID NO:57 or an amino acid sequence that has at least 80% identity with SEQ ID NO:57, and wherein the polypeptide has binding activity for a β2AR. 2. The polypeptide according to claim 1 comprising an amino acid sequence that has at least 80% identity with an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:5. 3. A composition comprising the polypeptide according to claim 1 . 4. A composition comprising the polypeptide according to claim 2 .
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- What does patent US10078088B2 cover?
- The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the sta…
- Who is the assignee on this patent?
- Vib Vzw, Univ Brussel Vrije, Univ Leland Stanford Junior
- What technology area does this patent fall under?
- Primary CPC classification C07K14/705. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 18 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).