Methods for Nucleic Acid Cleavage
US-2024417778-A1 · Dec 19, 2024 · US
Sorbents for extraction and stabilization of nucleic acids
US10077465B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10077465-B2 |
| Application number | US-201615264021-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 13, 2016 |
| Priority date | Sep 13, 2016 |
| Publication date | Sep 18, 2018 |
| Grant date | Sep 18, 2018 |
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- Title
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Abstract
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Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of storing a nucleic acid comprising: contacting the nucleic acid with a mesoporous ethane-bridged silica sorbent with both N5 and CuEDA, thereby causing the nucleic acid to releasably bind to the sorbent. 2. The method of claim 1 , further comprising an initial step of washing the sorbent with a detergent prior to said contacting. 3. The method of claim 1 , further comprising a step of eluting the nucleic acid from the sorbent following binding. 4. The method of claim 1 , wherein said contacting occurs in a complex matrix comprises lysed cells. 5. The method of claim 1 , wherein said nucleic acid comprises RNA. 6. The method of claim 1 , wherein said sorbent is associated with a stabilizer. 7. The method of claim 6 , wherein said stabilizer is selected from the group consisting of bovine serum albumin, trehalose, and glucosamine.
Assignees
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Classifications
- C12Q1/6806Primary
Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay (C12Q1/6804 takes precedence) · CPC title
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Frequently asked questions
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- What does patent US10077465B2 cover?
- Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.
- Who is the assignee on this patent?
- Us Navy
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6806. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 18 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).