Synthetic route to anti-viral agents
US-9809576-B1 · Nov 7, 2017 · US
US10077256B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10077256-B2 |
| Application number | US-201715804485-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 6, 2017 |
| Priority date | Jul 18, 2014 |
| Publication date | Sep 18, 2018 |
| Grant date | Sep 18, 2018 |
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The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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We claim: 1. A compound selected from the group consisting of: salts thereof. 2. The compound of claim 1 , wherein the compound is or a salt thereof. 3. The compound of claim 1 , wherein the compound is or a salt thereof. 4. The compound of claim 1 , wherein the compound is or a salt thereof. 5. The compound of claim 1 , wherein the compound is or a salt thereof. 6. The compound of claim 1 , wherein the compound is or a salt thereof. 7. The compound of claim 1 , wherein the compound is or a salt thereof. 8. The compound of claim 1 , wherein the compound is or a salt thereof. 9. The compound of claim 1 , wherein the compound is or a salt thereof. 10. The compound of claim 1 , wherein the compound is or a salt thereof. 11. The compound of claim 1 , wherein the compound is or a salt thereof. 12. The compound of claim 1 , wherein the compound is or a salt thereof. 13. The compound of claim 1 , wherein the compound is or a salt thereof. 14. The compound of claim 1 , wherein the compound is
by esterification of carboxylic acid groups in the enantiomers or the inverse reaction · CPC title
from amines with formation of carbamate groups · CPC title
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
by reactions not involving the formation of carbamate groups · CPC title
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