Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
US-9315464-B1 · Apr 19, 2016 · US
US10076529B1 · US · B1
| Field | Value |
|---|---|
| Publication number | US-10076529-B1 |
| Application number | US-201615068379-A |
| Country | US |
| Kind code | B1 |
| Filing date | Mar 11, 2016 |
| Priority date | Jan 31, 2013 |
| Publication date | Sep 18, 2018 |
| Grant date | Sep 18, 2018 |
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Compositions, compounds, and methods with significant antiviral effect against RNA viruses and especially orthomyxoviruses are contemplated, and target the viral promoter that is formed by the 5′ and 3′-UTR sequences of the viral genome.
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The invention claimed is: 1. A pharmaceutical composition comprising N-(4-(N-(quinoxalin-2-yl)sulfamoyl)phenyl)-2-(p-tolyl)quinoline-4-carboxamide; wherein the compound is present in the composition in an amount effective to reduce viral propagation of a virus belonging to the family of an orthomyxoviridae when the composition is administered to a person in need thereof.
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone · CPC title
Physics · mapped topic
Non-condensed quinolines and containing further heterocyclic rings · CPC title
not condensed and containing further heterocyclic rings · CPC title
1,3-Thiazoles · CPC title
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