Uncaging stent

Patent metadata

Field	Value
Publication number	US-10076431-B2
Application number	US-201815921508-A
Country	US
Kind code	B2
Filing date	Mar 14, 2018
Priority date	May 16, 2016
Publication date	Sep 18, 2018
Grant date	Sep 18, 2018

Abstract

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

First claim

What is claimed is:

1. An endoluminal prosthesis comprising:
a scaffold comprising structural elements comprising a plurality of circumferential rings patterned from a first material comprising a non-degradable material, said scaffold being configured to expand from a crimped configuration to an expanded configuration;
wherein at least some of the circumferential rings comprise a plurality of struts joined by crowns;
wherein at least some of the circumferential rings have at least one separation region comprising a break or a gap in said rings;
wherein said at least one separation region comprises a lock and key having a geometry configured to hold the separation region together during expansion, said lock containing said key at least in part, said lock and key both being located within the same circumferential ring, said lock and key being configured to be held together during expansion and move apart only after expansion in a physiologic environment.

2. An endoluminal prosthesis as in claim 1 , wherein the separation region is located in a strut, crown, and/or circumferential connector.

3. An endoluminal prosthesis as in claim 1 , wherein said lock and key is configured to provide a surface area and/or feature sufficient to provide adhesion or friction to prevent premature separation upon expansion of said scaffold.

4. An endoluminal prosthesis comprising:
a scaffold comprising structural elements comprising a plurality of circumferential rings patterned from a first material comprising a non-degradable material, said scaffold being configured to expand from a crimped configuration to an expanded configuration;
wherein at least some of the circumferential rings comprise a plurality of struts joined by crowns;
wherein at least some of the circumferential rings have at least one separation region comprising a break or a gap in said rings;
wherein said at least one separation region comprises a lock and key, wherein said lock contains said key at least in part, and a second material configured to hold the lock and key together during expansion and providing a continuous circumferential path around the scaffold, said lock and key both being located within the same circumferential ring, wherein said separation region being configured to separate forming at least one discontinuity in said circumferential ring after expansion in a physiologic environment.

5. An endoluminal prosthesis as in claim 1 , wherein said separation region further comprises a second material comprising a degradable and/or non-degradable material comprising a polymer and/or adhesive providing a continuous circumferential path around the scaffold.

6. An endoluminal prosthesis as in claim 5 , wherein said second material comprises a degradable polymeric polymer and/or adhesive.

7. An endoluminal prosthesis as in claim 1 , wherein the circumferential rings are formed from bent wire forming a helical scaffold.

8. An endoluminal prosthesis as in claim 1 or claim 4 , wherein a plurality of circumferential rings of said scaffold have at least one separation region each comprising a lock and key located within said rings.

9. An endoluminal prosthesis as in claim 1 or claim 4 , wherein the separation region is located between two adjacent crowns or between two adjacent struts in said circumferential ring.

10. An endoluminal prosthesis as in claim 1 or claim 4 , wherein said lock and key comprises a ball and socket, disc and cap, tongue in slot, interlocking combs, interlocking teeth, interlocking hooks, grooves or V's or U's with suitable opposing shapes, or wavy or undulating interlocking surfaces.

11. An endoluminal prosthesis ad in claim 4 , wherein said at least one separation region is located in a strut, crown, and/or circumferential connector.

12. An endoluminal prosthesis as in claim 1 or claim 4 , wherein said first material comprises a non-degradable metal or metal alloy.

13. An endoluminal prosthesis as in claim 12 , wherein the non degradable metal or metal alloy comprises stainless steel, cobalt alloy, cobalt chrome, platinum, platinum iridium, platinum chromium, platinum rhodium, or nickel titanium.

14. An endoluminal prosthesis as in claim 4 , wherein the circumferential rings are formed from bent wire forming a helical scaffold.

15. An endoluminal prosthesis as in claim 1 or claim 4 , wherein the scaffold further comprises at least one drug.

16. An endoluminal prosthesis as in claim 15 , wherein the drug comprises an m-TOR inhibitor comprising sirolimus, novolimus, biolimus, everolimus, ridaforolimus, temsirolimus, or zotarolimus.

17. An endoluminal prosthesis as in claim 1 or claim 4 , wherein the scaffold further comprises a polymer coating, wherein the polymer coating comprises polylactide, poly-L-lactic acid, poly-DL-lactide, polylactide-co-glycolide, poly(lactic-co-glycolide), poly(n-butylmethacrylate), ethylene vinyl acetate, poly(ethylene-co-vinyl acetate), polyvinyl pyrrolidone, parylene, PVDF-HFP poly(vinylidene fluoride hexafluoropropylene), polystyrene, poly(L-lactide-co-epsilon-caprolactone), or poly(styrene-b-isobutylene-b-styrene).

18. An endoluminal prosthesis as in claim 1 or claim 4 , where said scaffold has a pattern comprising a serpentine, zigzag, or helical design.

19. An endoluminal prosthesis as in claim 4 , wherein the separation region is joined by, covered by, or embedded in said second material.

20. An endoluminal prosthesis as in claim 4 , wherein said second material comprises a biodegradable polymer and/or adhesive which degrades in the physiologic environment.

21. An endoluminal prosthesis as in claim 20 , wherein the biodegradable polymer and/or adhesive comprises polylactide, poly-L-lactide, poly-DL-lactide, polylactide-co-glycolide, poly(L-lactic-co-glycolide), poly(ethylene-co-vinyl acetate), poly(L-lactide-co-epsilon-caprolactone), poly(DL-lactide-co-glycolide), poly(lactide-co-caprolactone), poly(D-lactide), polyglycolide, polycaprolactone, polyhydroxyalkanoate, polyvinyl alcohol, polyvinyl acetate or cyanoacrylate.

22. An endoluminal prosthesis as in claim 1 or claim 4 , wherein said prosthesis following expansion from a crimped configuration to an expanded configuration in a physiologic environment has sufficient strength to support a body lumen and low recoil from said expanded configuration.

23. An endoluminal prosthesis as in claim 4 , wherein said second material comprises a non-degradable material.

24. An endoluminal prosthesis as in claim 23 , wherein said non-degradable material allows further expansion of the scaffold after recoil following an initial expansion.

25. An endoluminal prosthesis as in claim 23 , wherein said non-degradable material comprises an elastic material wherein said elastic material remains intact after expansion of the scaffold in physiologic environment.

26. An endoluminal prosthesis as in claim 4 , wherein said second material permits said key and lock to move in a radial, circumferential, and/or longitudinal direction after expansion in physiologic environment.

27. An endoluminal prosthesis as in claim 4 , wherein said separation region is immobilized during expansion but configured to separate after expansion in the physiologic environment.

28. An endoluminal prosthesis as in claim 1 or claim 10 , wherein portions of said lock and key remain overlapped upon expansion in a physiologic environment.

Assignees

• Elixir Medical Corp

Inventors

• Sirhan Motasim
• Yan John
• Bhat Vinayak
• Paraschac Joseph
• Cryer Brett
• Serna Benjamyn

Classifications

• A61F2220/0033

  made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit · CPC title

• A61F2250/0071

  breakable or frangible · CPC title

• A61F2230/0006

  circular · CPC title

• A61F2002/91575

  connected peak to trough · CPC title

• A61F2250/0031

  made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts · CPC title