Optical particle sorter

Patent metadata

Field	Value
Publication number	US-10073026-B2
Application number	US-201715632621-A
Country	US
Kind code	B2
Filing date	Jun 26, 2017
Priority date	Jul 5, 2016
Publication date	Sep 11, 2018
Grant date	Sep 11, 2018

Abstract

A process for optically sorting a plurality of particles includes: providing a particle receiver; producing particles; receiving the particles by the particle receiver; receiving a light by the particle receiver; producing a standing wave optical interference pattern in an optical interference site of the particle receiver from the light; subjecting the particles to an optical gradient force from the standing wave optical interference pattern; deflecting the particles into a plurality of deflected paths to form the sorted particles from the particles; and propagating the sorted particles from the optical interference site through the deflected paths to optically sort the particles.

First claim

What is claimed is:

1. An optical particle sorter comprising:
a particle receiver comprising:
a particle entrance that receives a plurality of particles;
an optical entrance that receives light and that is geometrically disposed at a non-parallel angle with respect to the particle entrance;
a sorted particle exit opposing the particle entrance and that communicates sorted particles from an optical interference site; and
the optical interference site interposed between the particle entrance and the sorted particle exit;

a first light source in optical communication with the particle receiver and that:
produces a first light; and
produces a standing wave optical interference pattern in the optical interference site of the particle receiver; and

a particle source in fluid communication with the particle receiver and that:
provides the particles; and
communicates the particles to the particle receiver at an acute angle with respect to the standing wave optical interference pattern 24 ,

wherein the optical particle sorter sorts the particles into a plurality of sorted particles that exit the particle receiver at the sorted particle exit, and
the sorted particles propagate in a plurality of deflected paths relative to a path of propagation of the particles at the particle entrance, the deflected path of individual sorted particles based on a sorting parameter comprising a dielectric constant, a magnetic permeability, a particle volume, or a combination comprising at least one of the foregoing sorting parameters of the particles.

2. The optical particle sorter of claim 1 , further comprising:
a second light source in optical communication with the particle receiver and that produces a second light,
wherein the second light in combination with the first light form the standing wave optical interference pattern in the optical interference site of the particle receiver.

3. The optical particle sorter of claim 1 , further comprising:
a first mirror disposed at the optical entrance; and
a second mirror disposed opposing the first mirror,
wherein the first mirror and the second mirror are arranged as an optical cavity.

4. The optical particle sorter of claim 3 , wherein the optical cavity comprises a Fabry Perot cavity.

5. The optical particle sorter of claim 1 , wherein the particle source provides a fluid, and the fluid propagates in a plurality of laminar streamlines from the particle source to the particle receiver.

6. The optical particle sorter of claim 5 , wherein the particles are disposed in the fluid and propagate along the laminar streamlines of the fluid from the particle source to the particle receiver.

7. The optical particle sorter of claim 1 , further comprising:
a collector that comprises a plurality of tubes disposed proximate to the sorted particle exit and distal to the particle entrance,
wherein the plurality of tubes comprises:
a first tube that receives first sorted particles that propagate at a first deflected path; and
a second tube that receives second sorted particles that propagate at a second deflected path.

8. The optical particle sorter of claim 7 , wherein the second deflected path is greater than the first deflected path.

9. The optical particle sorter of claim 8 , wherein individual second sorted particles have a second particle volume, and individual first sorted particles have a first particle volume that is less than the second particle volume.

10. The optical particle sorter of claim 1 , further comprising:
a particle detector that detects the sorted particles.

11. The optical particle sorter of claim 1 , wherein the particles comprise a protein.

12. The optical particle sorter of claim 1 , wherein a particle volume of the particles is from 1000 cubic nanometers (nm 3 ) to 100 cubic micrometers (μm 3 ).

13. A process for optically sorting a plurality of particles, the process comprising:
providing a particle receiver of claim 1 ;
producing the particles;
receiving the particles by the particle receiver;
receiving the first light by the particle receiver;
producing the standing wave optical interference pattern in the optical interference site of the particle receiver from the first light;
subjecting the particles to an optical gradient force from the standing wave optical interference pattern;
deflecting the particles into the plurality of deflected paths to form the sorted particles from the particles such that the deflected path of individual sorted particles is based on a sorting parameter comprising a dielectric constant, a magnetic permeability, a particle volume, or a combination comprising at least one of the foregoing sorting parameters of the particles; and
propagating the sorted particles from the optical interference site through the deflected paths to the sorted particle exit that opposes the particle entrance to optically sort the particles.

14. The process for optically sorting a plurality of particles of claim 13 , further comprising:
providing a second light from a second light source in optical communication with the particle receiver; and
forming the standing wave optical interference pattern by combining the first light and the second light.

15. The process for optically sorting a plurality of particles of claim 13 , further comprising:
providing a fluid from the particle source; and
propagating the fluid in a plurality of laminar streamlines from the particle source to the particle receiver.

16. The process for optically sorting a plurality of particles of claim 15 , wherein the particles are disposed in the fluid and propagate along the laminar streamlines of the fluid from the particle source to the particle receiver.

17. The process for optically sorting a plurality of particles of claim 13 , further comprising:
collecting the particles by a collector comprising a plurality of tubes disposed proximate to the sorted particle exit and distal to the particle entrance,
wherein the plurality of tubes comprises:
a first tube that receives first sorted particles that propagate at a first deflected path; and
a second tube that receives second sorted particles that propagate at a second deflected path.

18. The process for optically sorting a plurality of particles of claim 17 , wherein the second deflected path is greater than the first deflected path.

19. The optical particle sorter of claim 18 , wherein individual second sorted particles have a second particle volume, and individual first sorted particles have a first particle volume that is less than the second particle volume.

Assignees

• Us Commerce

Inventors

• Curry John J
• Levine Zachary H

Classifications

• G21K1/30

  for confining neutral particles or handling confined neutral particles, e.g. atom traps · CPC title

• G01N15/1434 Primary

  Optical arrangements · CPC title

• G01N15/1404

  Handling flow, e.g. hydrodynamic focusing · CPC title

• G01N2015/0038

  Investigating nanoparticles · CPC title

• G01N2015/149

  Physics · mapped topic