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US-2024190925-A1 · Jun 13, 2024 · US
Astexin peptides
US10072048B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10072048-B2 |
| Application number | US-201314424617-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 29, 2013 |
| Priority date | Aug 31, 2012 |
| Publication date | Sep 11, 2018 |
| Grant date | Sep 11, 2018 |
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Abstract
Official abstract text for this publication.
Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus , and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus , a bacterium related to Asticaccaulis excentricus . The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
First claim
Opening claim text (preview).
What is claimed is: 1. A substantially purified Astexin-1 peptide consisting of the amino acid sequence GLSQGVEPEIGQTYFEESRINQD (SEQ ID NO:48), wherein in SEQ ID NO:48 the glycine residue (G) at position 1 is covalently bound to the glutamic acid residue (E) at position 9, thereby generating a lassoed peptide. 2. The peptide of claim 1 , wherein the C-terminal amino acid of the peptide comprises a protecting group. 3. A non-naturally occurring polynucleotide sequence encoding the peptide of claim 1 .
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Classifications
- C07K14/195Primary
from bacteria · CPC title
containing heavy metals, in the bonded or free state · CPC title
by chemical fixing the harmful substance, e.g. by chelation or complexation · CPC title
using natural organic sorbents or derivatives thereof · CPC title
Heavy metals or heavy metal compounds · CPC title
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- What does patent US10072048B2 cover?
- Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus , and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus , a bacterium related to Asticaccaulis excentricus . The s…
- Who is the assignee on this patent?
- Univ Princeton
- What technology area does this patent fall under?
- Primary CPC classification C07K14/195. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 11 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).