Crystal of ammonium N-acetylneuraminate anhydrate, and process for producing same

Patent metadata

Field	Value
Publication number	US-10072038-B2
Application number	US-201615545881-A
Country	US
Kind code	B2
Filing date	Jan 27, 2016
Priority date	Jan 28, 2015
Publication date	Sep 11, 2018
Grant date	Sep 11, 2018

Abstract

According to the present invention, a crystal of ammonium N-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an ammonium-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of ammonium N-acetylneuraminate anhydrate, and collecting the crystal of ammonium N-acetylneuraminate anhydrate from the aqueous solution, can be provided.

First claim

The invention claimed is:

1. A crystal of ammonium N-acetylneuraminate anhydrate.

2. The crystal according to claim 1 , wherein the crystal has peaks at diffraction angles (2θ) of 12.3±0.2°, 13.7±0.2°, 14.2±0.2°, 22.4±0.2°, and 22.6±0.2° in powder X-ray diffraction.

3. The crystal according to claim 2 , wherein the crystal further has peaks at diffraction angles (2θ) of 17.1±0.2°, 21.2±0.2°, 21.6±0.2°, 23.5±0.2°, and 24.8±0.2° in powder X-ray diffraction.

4. The crystal according to claim 3 , wherein the crystal further has peaks at diffraction angles (2θ) of 27.7±0.2°, 28.1±0.2°, 28.4±0.2°, 28.6±0.2°, and 42.3±0.2° in powder X-ray diffraction.

5. A process for producing a crystal of ammonium N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an ammonium-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of ammonium N-acetylneuraminate anhydrate, and collecting the crystal of ammonium N-acetylneuraminate anhydrate from the aqueous solution.

6. The production process according to claim 5 , wherein the solvent selected from the group consisting of alcohols and ketones is a solvent selected from C1-C6 alcohols, acetone, methyl ethyl ketone, and diethyl ketone.

Assignees

• Kyowa Hakko Bio Co Ltd

Inventors

• Fukumoto Kazunari

Classifications

• C07B2200/13

  Crystalline forms, e.g. polymorphs · CPC title

• C07H13/04 Primary

  having the esterifying carboxyl radicals attached to acyclic carbon atoms · CPC title

• C07H7/027

  Keto-aldonic acids · CPC title

• C07H5/06 Primary

  Aminosugars · CPC title

• C07H1/00 Primary

  Processes for the preparation of sugar derivatives · CPC title