N-substituted benzamides and methods of use thereof
US-2015224071-A1 · Aug 13, 2015 · US
N-substituted benzamides and methods of use thereof
US10071957B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10071957-B2 |
| Application number | US-201314413218-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 5, 2013 |
| Priority date | Jul 6, 2012 |
| Publication date | Sep 11, 2018 |
| Grant date | Sep 11, 2018 |
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Abstract
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The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X 2 , L, subscript m, X 1 , ring D, R 1 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
First claim
Opening claim text (preview).
We claim: 1. A compound selected from the group consisting of: 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-sulfamoylbenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(N- methylsulfamoyl)benzamide 5-chloro-4-(4-chloro-3- (trifluoromethyl)phenoxy)-2- fluoro-N-sulfamoylbenzamide 5-chloro-4-(4-chloro-3- (trifluoromethyl)phenoxy)-2- fluoro-N-(N- methylsulfamoyl)benzamide 5-chloro-4-(3-chloro-4- (trifluoromethoxy)phenoxy)-2- fluoro-N-sulfamoylbenzamide 5-chloro-4-(3-chloro-4- (trifluoromethoxy)phenoxy)-2- fluoro-N-(N- methylsulfamoyl)benzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-N- (N,N-dibutylsulfamoyl)-2- fluorobenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(pyrrolidin-1- ylsulfonyl) benzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(piperidin-1- ylsulfonyl)benzamide N-(azepan-1-ylsulfonyl)-5- chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluorobenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(N-isopropyl-N- methylsulfamoyl) benzamide N-(N-benzylsulfamoyl)-5-chloro- 4-((5-chloro-6-isobutoxypyridin- 3-yl)oxy)-2-fluorobenzamide N-(N-benzyl-N- methylsulfamoyl)-5-chloro-4- ((5-chloro-6-isobutoxypyridin-3- yl)oxy)-2-fluorobenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(N-(pyridin-2- ylmethyl)sulfamoyl)benzamide 2,2,2-trifluoroacetate 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-N-(N- (4-cyanophenyl)sulfamoyl)-2- fluorobenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(N-(pyridin-3- ylmethyl)sulfamoyl)benzamide 2,2,2-trifluoroacetate 5-chloro-4-((3,4- dichlorobenzyl)oxy)-N-(N,N- dimethylsulfamoyl)-2- fluorobenzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-((1-methyl-1H- imidazol-4- yl)sulfonyl)benzamide 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(indolin-1- ylsulfonyl)benzamide N-((1H-imidazol-4-yl)sulfonyl)-5- chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluorobenzamide 1-(N-(5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluorobenzoyl)sulfamoyl)piperidine- 4-carboxylate 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(pyridin-3- ylsulfonyl)benzamide tert-butyl N-(5-chloro-4-((5- chloro-6-isobutoxypyridin-3- yl)oxy)-2- fluorobenzoyl)sulfamoylcarbamate 4-(3-chloro-4- (trifluoromethoxy)phenoxy)-N- (N,N-dimethylsulfamoyl)-2,5- difluorobenzamide N-(N,N-dimethylsulfamoyl)-4- fluoro-6-((5-methyl-3- phenylisoxazol-4- yl)methoxy)nicotinamide 5-chloro-4-((5-chloro-6-(2,2,3,3- tetrafluoropropoxy)pyridin-3- yl)oxy)-2-fluoro-N-(N- methylsulfamoyl)benzamide 5-chloro-4-((5,6- dichloropyridin-3-yl)oxy)-2- fluoro-N-sulfamoylbenzamide 5-chloro-4-((5,6- dichloropyridin-3-yl)oxy)-N- (N,N-dimethylsulfamoyl)-2- fluorobenzamide 5-chloro-4-(((5-chloro-6- (2,2,3,3- tetrafluoropropoxy)pyridin-3- yl)oxy)methyl)-2-fluoro-N- sulfamoylbenzamide 5-chloro-4-((5-chloro-6-(2,2,3,3- tetrafluoropropoxy)pyridin-3- yl)oxy)-2-fluoro-N- sulfamoylbenzamide 5-chloro-4-((5,6- dichloropyridin-3-yl)oxy)-2- fluoro-N-(N- methylsulfamoyl)benzamide 5-chloro-N-(N,N- dimethylsulfamoyl)-2-fluoro-4- ((6-isobutoxy-5- (trifluoromethyl)pyridin-3- yl)oxy)benzamide tert-butyl 4-(N-(5-chloro-4-((5- chloro-6-isobutoxypyridin-3- yl)oxy)-2- fluorobenzoyl)sulfamoyl)piperazine- 1-carboxylate 5-chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluoro-N-(piperazin-1- ylsulfonyl)benzamide 5-chloro-4-(4-cyanophenoxy)-N- (N,N-dimethylsulfamoyl)-2- fluorobenzamide 5-chloro-N-(N,N- dimethylsulfamoyl)-2-fluoro-4- (4-(thiazol-2- yl)phenoxy)benzamide 5-chloro-4-(3-chloro-4- (trifluoromethoxy)phenoxy)-N- (N-cyclobutylsulfamoyl)-2- fluorobenzamide N-(azetidin-1-ylsulfonyl)-5- chloro-4-((5-chloro-6- isobutoxypyridin-3-yl)oxy)-2- fluorobenzamide 5-chloro-N-(N,N- dimethylsulfamoyl)-2-fluoro-4- (naphthalen-2-yloxy)benzamide 5-chloro-2-fluoro-4- (naphthalen-2-yloxy)-N- sulfamoylbenzamide
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of the thyroid hormones, e.g. T3, T4 · CPC title
Antiarrhythmics · CPC title
Drugs for disorders of the cardiovascular system · CPC title
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
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- What does patent US10071957B2 cover?
- The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X 2 , L, subscript m, X 1 , ring D, R 1 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
- Who is the assignee on this patent?
- Genentech Inc, Xenon Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C07C307/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 11 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).