Pharmaceutical packaging with lubricating film and method for producing same

Patent metadata

Field	Value
Publication number	US-10071397-B2
Application number	US-201013395602-A
Country	US
Kind code	B2
Filing date	Sep 14, 2010
Priority date	Sep 14, 2009
Publication date	Sep 11, 2018
Grant date	Sep 11, 2018

Abstract

A pharmaceutical packaging comprising a silicone-free lubricating film of crosslinked organic molecules. The method for producing the pharmaceutical packaging comprises: applying a silicone-free organic fluid as a film on a surface of a hollow substrate for the lubricating film; placing the substrate in a vacuum reactor; evacuating the vacuum reactor; generating an alternating electromagnetic field by an AC voltage source; and introducing the alternating electromagnetic field into the interior of the substrate, a field strength thereof in the gas which is present in or introduced into the evacuated cavity of the substrate being sufficient to cause a homogeneous glow discharge under the pressure prevailing in the cavity of the substrate.

First claim

The invention claimed is:

1. A method for producing a lubricating film on an inner surface of a pharmaceutical container, the method comprising:
applying a silicone-free organic fluid as a film on the inner surface of the pharmaceutical container serving as a substrate for the lubricating film;
placing the pharmaceutical container in a vacuum reactor;
evacuating the vacuum reactor to evacuate a cavity of the pharmaceutical container;
generating an alternating electromagnetic field by an AC voltage source; and
introducing the alternating electromagnetic field into the cavity of the pharmaceutical container, a field strength thereof in a gas, which is present in or introduced into the evacuated cavity of the pharmaceutical container, being sufficient to cause a homogeneous low-pressure glow discharge under a pressure prevailing in the cavity of the pharmaceutical container;
wherein the film is subjected to gas particles ionized during the glow discharge and accelerated in the alternating electromagnetic field and to the electrons generated during ionization,
wherein the gas particles by virtue of their energy input break bonds in molecules of the film which as a result thereof cause crosslinking, so that a crosslinked lubricating film is produced, wherein with crosslinking a surface energy of the lubricating film is reduced,
wherein organic residues on the inner surface of the pharmaceutical container are removed by plasma in a surface pre-treatment prior to applying the silicone-free organic fluid,
wherein the pressure of the gas and the field strength of said alternating electromagnetic field are selected such that the glow discharge occurring in the cavity of the pharmaceutical container is abnormal and exhibits a current-voltage characteristic with a positive slope, the pressure of the gas being less than 100 millibars,
wherein an electrode is disposed in the cavity of the pharmaceutical container, and the alternating electromagnetic field is generated by applying an AC voltage between said electrode in the cavity of the pharmaceutical container and an outer electrode, and
wherein the electrode in the cavity is a hollow tube comprising at least one opening and a passage connected with the at least one opening through which the cavity is evacuated and process gas is removed during the low-pressure glow discharge treatment.

2. The method as claimed in claim 1 , wherein the lubricating film is applied by means of a dual-material nozzle or a single-material atomizer, through spray-depositing onto the inner surface of the pharmaceutical container.

3. The method as claimed in claim 1 , wherein a fluid quantity in a range from 0.004 μl/cm 2 to 2.8 μl/cm 2 is applied to the inner surface of the pharmaceutical container.

4. The method as claimed in claim 1 , wherein the low-pressure glow discharge is excited by a medium-frequency source with a frequency below 120 kHz.

5. The method as claimed in claim 1 , wherein, during the low-pressure glow discharge an alternating current is adjusted to an average current strength in a range from 0.1 mA to 500 mA.

6. The method as claimed in claim 1 , wherein a fluid quantity in a range from 0.009 μl/cm 2 to 0.22 μl/cm 2 is applied to the inner surface of the pharmaceutical container.

7. The method as claimed in claim 1 , wherein the low-pressure glow discharge is excited by a medium-frequency source in a range from 40 to 110 kHz.

8. The method as claimed in claim 1 , wherein the low-pressure glow discharge is excited by a medium-frequency source in a range from 60 to 100 kHz.

9. The method as claimed in claim 1 , wherein, during the low-pressure glow discharge an alternating current is adjusted to an average current strength in a range from 1 mA to 200 mA.

10. The method as claimed in claim 1 , wherein, during the low-pressure glow discharge an alternating current is adjusted to an average current strength in a range from 3 mA to 100 mA.

11. A method for producing a lubricating film on an inside of a pharmaceutical container, the method comprising:
applying a silicone-free organic fluid as a film on the inside of the pharmaceutical container serving as a substrate for the lubricating film,
wherein the silicone-free fluid includes fluoroalkyl and/or ethylene groups;
placing the pharmaceutical container in a vacuum reactor;
evacuating the vacuum reactor to evacuate a cavity of the pharmaceutical container;
generating an alternating electromagnetic field by an AC voltage source; and
introducing the alternating electromagnetic field into the cavity of the pharmaceutical container, a field strength thereof in the gas, which is present in or introduced into the evacuated cavity of the pharmaceutical container, being sufficient to cause a homogeneous low-pressure glow discharge under a pressure prevailing in the cavity of the pharmaceutical container;
wherein the film is subjected to gas particles ionized during the glow discharge and accelerated in the alternating electromagnetic field and to electrons generated during ionization,
wherein the gas particles by virtue of their energy input break bonds in molecules of the film which as a result thereof cause crosslinking, so that a crosslinked lubricating film is produced, wherein with crosslinking a surface energy of the lubricating film is reduced,
wherein an average power per unit mass flow <P>/F introduced by the alternating electromagnetic field is in a range from 2×10 −1 W/sccm to 1×10 2 W/sccm, whereby the surface energy of a surface of the lubricating film is reduced by at least 10 mN/m and a maximum of 36 mN/m,
wherein the pressure of the gas and the field strength of said alternating electromagnetic field are selected such that the glow discharge occurs in the cavity of the pharmaceutical container is abnormal and exhibits a current-voltage characteristic with a positive slope, the pressure of the gas being less than 100 millibars,
wherein an electrode is disposed in the cavity of the pharmaceutical container, and the alternating electromagnetic field is generated by applying an AC voltage between said electrode in the cavity of the pharmaceutical container and an outer electrode, and
wherein the electrode in the cavity is a hollow tube comprising at least one opening and a passage connected with the at least one opening through which the cavity is evacuated and process gas is removed during the low-pressure glow discharge treatment, so that a contact angle for water in the lubricating film is obtained in a range from 60° to 140°.

12. The method as claimed in claim 11 wherein, by virtue of the low-pressure glow discharge, both polar and disperse components of the surface energy are reduced simultaneously, which is associated with a liquid-repellent wetting behavior for liquids having different levels of polar and disperse components.

13. The method as claimed in claim 11 wherein a mass flow in a range from 1 sccm to 800 sccm is employed for the low-pressure glow discharge, whereby a homogeneous plasma zone is formed in the region of the cavity.

14. A method for producing a lubricating film on an inner surface of a pharmaceutical container, the method comprising:
applying a silicone-free organic fluid as a film on the inner surface of the pharmaceutical container serving as a substrate for the lubricating film;
placing the pharmaceutical container in a vacuum reactor;
evacuating the vacuum reactor to evacuate a cavity of the pharmaceutical container;
generating an alternating electromagnetic field by an AC voltage source; and
introducing the alternating electromagnetic field into the cavity of the pharmaceutical container, a

Assignees

• Bicker Matthias
• Bauch Hartmut
• Lohmeyer Manfred
• Schott Ag

Inventors

• Bicker Matthias
• Bauch Hartmut
• Lohmeyer Manfred

Classifications

• B05D3/147

  Curing · CPC title

• B05D3/141

  Plasma treatment · CPC title

• B05D7/22

  to internal surfaces, e.g. of tubes · CPC title

• B05D3/0493

  using vacuum · CPC title

• B05D1/62

  Plasma-deposition of organic layers (plasma deposition in general C23C14/00, C23C16/00) · CPC title