Method for preparing hydrogel bead for detection of hydrofluoric acid and kit comprising the same

Patent metadata

Field	Value
Publication number	US-10067104-B2
Application number	US-201514693346-A
Country	US
Kind code	B2
Filing date	Apr 22, 2015
Priority date	Nov 25, 2014
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

The present invention relates to a hydrogel bead for detecting hydrofluoric acid and a kit comprising the same, and more particularly, to a hydrogel bead capable of detecting hydrofluoric acid using an organometallic ligand compound that reversibly changes color depending on the concentration of hydrofluoric acid when coming into contact with hydrofluoric acid, and to a kit for detecting hydrofluoric acid comprising the same. In an embodiment, a method for preparing a hydrogel bead for detecting hydrofluoric acid comprises the steps of: mixing an organic compound, which contains an aromatic functional group having at least one hydroxyl group bonded thereto, with a solution of a metal-ligand compound that bonds with the organic compound, thereby preparing a mixed solution; dropping the mixed solution onto a gelling agent; and adding coagulating agent to the mixture resulting from the dropping step to form a porous bead.

First claim

What is claimed is:

1. A method for preparing a hydrogel bead for detecting hydrofluoric acid, comprising the steps of:
mixing an organic compound, which contains an aromatic functional group having at least one hydroxyl group bonded thereto, with a solution of a metal-ligand compound that bonds with the organic compound, thereby preparing a mixed solution;
dropping the mixed solution onto a gelling agent; and
adding coagulating agent to the mixture resulting from the dropping step to form a porous bead,
wherein the organic compound comprises a compound represented by the following formula 1:

wherein R 1 and R 2 may be the same or different and are each a cyclic group having 4 to 10 carbon atoms, and R 3 is selected from the group consisting of a hydroxyl group, a nitrile group and hydrogen, wherein the metal-ligand compound is represented by the following formula 2:

wherein M is a titanium (Ti) ion; X 1 to X 4 are each independently selected from the group consisting of oxygen, nitrogen and carbon atoms; Li and L2 are each an atom group forming a bidentate ligand; Sol is a solution that is capable of coordinating to metal ions and contains one selected from the group consisting of a hydroxyl-containing group, an amine-containing group, an amide-containing group, and combinations thereof and/or water,
wherein the coagulating agent is at least one selected from the group consisting of potassium chloride, sodium chloride, magnesium chloride, and calcium chloride,
wherein the gelling agent is at least one selected from the group consisting of alginate, natural gum, gelatin, pectin, arabinogalactan, agar, carrageenan, furcellaran and modified starch, and
wherein the organic compound is pyrocatechol violet.

2. A method for preparing a hydrogel bead for detecting hydrofluoric acid, comprising the steps of:
mixing a gelling agent with a coagulating agent to prepare a porous bead;
mixing an organic compound, which contains an aromatic functional group having at least one hydroxyl group bonded thereto, with a solution of a metal-ligand compound that bonds with the organic compound, thereby preparing a mixed solution; and
impregnating the mixed solution into the porous bead, wherein the organic compound comprises a compound represented by the following formula 1:

wherein R 1 and R 2 may be the same or different and are each a cyclic group having 4 to 10 carbon atoms, and R 3 is selected from the group consisting of a hydroxyl group, a nitrile group and hydrogen,
wherein the metal-ligand compound is represented by the following formula 2:

wherein M is a titanium (Ti) ion; X 1 to X 4 are each independently selected from the group consisting of oxygen, nitrogen and carbon atoms; L1 and L2 are each an atom group forming a bidentate ligand; Sol is a solution that is capable of coordinating to metal ions and contains one selected from the group consisting of a hydroxyl-containing group, an amine-containing group, an amide-containing group, and combinations thereof, and/or water,
wherein the coagulating agent is at least one selected from the group consisting of potassium chloride, sodium chloride, magnesium chloride, and calcium chloride,
wherein the gelling agent is at least one selected from the group consisting of alginate, natural gum, gelatin, pectin, arabinogalactan, agar, carrageenan, furcellaran and modified starch, and
wherein the organic compound is pyrocatechol violet.

Assignees

• Univ Yonsei Iacf

Inventors

• Lee Sang Yup
• Lee Chaemyeong
• Kim Min Chul
• Kwak Jin Young
• Park Sang Woo
• Lim Young Jun
• Keum Chang Joon

Classifications

• G01N31/02

  using precipitation {(measuring deposition or liberation of materials from an electrolyte G01N27/42)} · CPC title

• G01N31/221

  for investigating pH value · CPC title

• G01N31/22 Primary

  using chemical indicators (G01N31/02 takes precedence) · CPC title

• G01N24/088

  Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics · CPC title

• G01N31/222

  for investigating moisture content · CPC title