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Methods of generating antibodies to metalloenzymes
US10066024B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10066024-B2 |
| Application number | US-201113882192-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 27, 2011 |
| Priority date | Oct 28, 2010 |
| Publication date | Sep 4, 2018 |
| Grant date | Sep 4, 2018 |
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- Title
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- Abstract
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- First independent claim
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Abstract
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Antibodies generated by this method are also disclosed as well as uses thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. An antibody comprising an antigen recognition region which binds to the synthetic zinc-mimicry epitope wherein R is O—CH 2 —CH 2 —CONH—CH 2 —CH 2 —NH 2 , wherein said antibody is obtainable by immunizing a subject with: (i) said synthetic zinc-mimicry epitope; and (ii) matrix metalloproteinase-7 (MMP-7). 2. The antibody of claim 1 attached to a detectable moiety or a therapeutic moiety. 3. A pharmaceutical composition comprising the antibody of claim 1 . 4. A method of detecting MMP-7 expression in a subject, the method comprising contacting a sample from the subject with the antibody of claim 1 , and detecting expression of MMP-7.
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Classifications
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
- C07K16/40Primary
against enzymes · CPC title
against material not provided for elsewhere {, e.g. haptens, metals, DNA, RNA, amino acids} · CPC title
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Frequently asked questions
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- What does patent US10066024B2 cover?
- Antibodies generated by this method are also disclosed as well as uses thereof.
- Who is the assignee on this patent?
- Sagi Irit, SELA PASWELL Netta, Grossman Moran, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 04 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).