Multi-well tray and rack therefore

Patent metadata

Field	Value
Publication number	US-10065190-B2
Application number	US-201715604791-A
Country	US
Kind code	B2
Filing date	May 25, 2017
Priority date	Mar 14, 2013
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.

First claim

What is claimed is:

1. A multi-well tray for use in an automated process comprising:
a base; and
one or more sets of wells, wherein each set of wells comprises:
a receptacle cap well formed in the base and comprising a side wall and a bottom wall defining interior surfaces of the receptacle cap well and a protrusion projecting upward from the bottom wall; and
a receptacle well formed in the base and comprising a side wall defining an interior surface of the receptacle well and a ledge extending from the side wall of the receptacle well and defining a perimeter of an end of a through-hole.

2. The multi-well tray of claim 1 , wherein the ledge of each receptacle well is an annular ledge.

3. The multi-well tray of claim 1 , wherein each receptacle cap well further comprises a plurality of tabs protruding inwardly from the side wall of the receptacle cap well and configured to securely engage a portion of a receptacle cap deposited in the receptacle cap well to prevent the receptacle cap from dislodging from the multi-well tray.

4. The multi-well tray of claim 1 , wherein each receptacle well further comprises a plurality of legs protruding inwardly from the side wall of the receptacle well and configured to securely engage a portion of a receptacle deposited in the receptacle well to prevent the receptacle from dislodging from the receptacle well.

5. The multi-well tray of claim 1 , wherein the side walls of the receptacle cap well and the receptacle well include cylindrical portions.

6. The multi-well tray of claim 1 , wherein the through-hole of the receptacle well is tapered to conform to a conical shape of a receptacle deposited in the receptacle well.

7. The multi-well tray of claim 1 , further comprising a receptacle cap deposited in at least one of the receptacle cap wells, wherein the receptacle cap comprises:
a hollow upper portion defining an open upper end configured to be engaged by an automated receptacle transport mechanism;
a lower portion defining a hollow space configured to receive the protrusion of the receptacle cap well; and
a flange dividing the upper portion from the lower portion.

8. The multi-well tray of claim 7 , wherein each receptacle cap well further comprises a plurality of tabs protruding inwardly from the side wall of the receptacle cap well and engaged with the flange of the receptacle cap to prevent the receptacle cap from dislodging from the multi-well tray.

9. The multi-well tray of claim 1 , further comprising a receptacle deposited in at least one of the receptacle wells, wherein the receptacle comprises:
an upper portion defining an open upper end;
a lower portion extending through the through-hole and defining a closed lower end of the receptacle; and
a ring formed on an outer surface of the receptacle, wherein the ring is supported on the ledge.

10. The multi-well tray of claim 9 , wherein each receptacle well further comprises a plurality of legs protruding inwardly from the side wall of the receptacle well and engaged with the ring of the receptacle to prevent the receptacle from dislodging from the receptacle well.

11. The multi-well tray of claim 9 , further comprising a receptacle cap deposited in at least one of the receptacle cap wells, wherein the receptacle cap comprises:
a hollow upper portion defining an open upper end configured to be engaged by an automated receptacle transport mechanism; and
a lower portion configured to be inserted into the open upper end of the receptacle.

12. The multi-well tray of claim 9 , wherein at least part of the upper portion of the receptacle is cylindrical, at least part of the lower portion of the receptacle is conical, and the through-hole of the receptacle well is tapered to conform to the conical shape of the lower portion of the receptacle.

13. The multi-well tray of claim 1 , further comprising a card insert removably securable to the base, wherein each set of wells further comprises a reagent well formed in the card insert.

14. The multi-well tray of claim 13 , wherein the wells of each set of wells are disposed in alignment with each other.

15. The multi-well tray of claim 13 , further comprising a lyophilized reagent contained in at least one reagent well, and wherein the at least one reagent well is sealed with a frangible seal.

16. The multi-well tray of claim 13 , further comprising one or more locking arms disposed on the card insert for locking engagement with the base.

17. The multi-well tray of claim 13 , wherein the reagent well is defined by a side wall and a bottom wall, and wherein the receptacle well further comprises one or more features selected from the group consisting of a plurality of bumps, a concave groove, a convex ridge, and a set of grooves and/or ridges comprising a crisscross pattern formed in a surface of the bottom wall.

18. The multi-well tray of claim 13 , wherein the reagent well further comprises one or more retention features selected from the group consisting of a tapered ring insert, a collar, a fingered collar, an annular ring, and a screw thread, wherein the one or more retention features are disposed within the reagent well and are sized to retain a lyophilized reagent within the reagent well.

19. The multi-well tray of claim 13 , wherein the base and the card insert are formed from plastic, and wherein the card insert is formed of a plastic having lower permeability to moisture than the plastic forming the base.

20. The multi-well tray of claim 1 , further comprising one or more locking fingers disposed on a side surface of the base for releasably engaging a rack for holding a plurality of multi-well trays.

Assignees

• Gen Probe Inc

Inventors

• Buse David
• Knight Byron J
• Groeli Julian

Classifications

• B01L2300/0838

  Capillaries · CPC title

• B01L2300/0829

  Multi-well plates; Microtitration plates · CPC title

• B01L3/50825

  Closing or opening means, corks, bungs · CPC title

• B65D39/0017

  Injection-molded plastic closures for "Champagne"- or "Sekt"-type bottles · CPC title

• B01L2300/044

  pierceable, e.g. films, membranes · CPC title