Blood processing filter and blood processing filter manufacturing method

Patent metadata

Field	Value
Publication number	US-10064989-B2
Application number	US-201415026467-A
Country	US
Kind code	B2
Filing date	Oct 2, 2014
Priority date	Oct 3, 2013
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a hard container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces, and a thickness of the filter element is compressed at the gripper to be 0.05 to 0.5 times the thickness.

First claim

The invention claimed is:

1. A blood processing filter for removing undesirable components from liquid containing a blood component or blood, the filter comprising:
a sheet-shaped filter element; and
a hard container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space,
wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces,
the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces,
a thickness of the filter element is compressed by the gripper to be 0.05 to 0.5 times the thickness,
at least one of the inlet-side container element and the outlet-side container element is provided with a rib on an inner surface, the rib being pressed against the filtering surface of the filter element, and
a coefficient of variation value of the thickness of the filter element is 6% or less.

2. The blood processing filter according to claim 1 , wherein the gripper compresses the filter element at a range with a width of 1 to 5 mm from an outermost edge, as the outer edge portion.

3. The blood processing filter according to claim 1 , wherein a coefficient of variation value of a distance from the inlet-side container element to an inlet-side surface of the filter element in the inlet space is 10% or less.

4. The blood processing filter according to claim 1 , wherein the gripper is in close contact with the end surface of the filter element.

5. The blood processing filter according to claim 1 , wherein the inlet-side container element and the outlet-side container element further include a fitting part from fitting portions surrounding the end surface of the filter element and fitted to one another.

6. The blood processing filter according to claim 5 , wherein the fitting portion includes an inlet-side fitting portion provided at the inlet-side container element, and an outlet-side fitting portion provided at the outlet-side container element, and
at least a part of a sliding surface between the inlet-side fitting portion and the outlet-side fitting portion is bonded along an entire periphery of the fitting portion with melt resin.

7. The blood processing filter according to claim 6 , wherein the sliding surface is provided with a resin flow path, the resin flow path is filled with the melt resin to bond the sliding surface.

8. The blood processing filter according to claim 1 , wherein the hard container is made of resin with a Young's modulus of at least 1 GPa at room temperature.

9. A method of manufacturing a blood processing filter for removing undesirable components from liquid containing a blood component or blood, the method comprising:
injection-molding an inlet-side container element using one mold, and an outlet-side container element using another mold;
inserting a filter element into the inlet-side container element or the outlet-side container element;
mold-fitting the molds, and fitting the inlet-side container element and the outlet-side container element to each other; and
bonding the inlet-side container element and the outlet-side container element to each other with melt resin,
wherein the filter element includes a pair of filtering surfaces, and an end surface along peripheries of the pair of the filtering surfaces,
the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces,
a thickness of the filter element is compressed at the gripper to be 0.05 to 0.5 times the thickness,
at least one of the inlet-side container element and the outlet-side container element is provided with a rib on an inner surface, the rib being pressed against the filtering surface of the filter element, and
a coefficient of variation value of the thickness of the filter element is 6% or less.

10. The blood processing filter according to claim 1 , wherein at least one of the inlet-side container element and the outlet-side container element is provided with a plurality of ribs including the rib, and
the ribs are configured to extend linearly and be arranged parallel to each other.

11. The method of manufacturing the blood processing filter according to claim 9 , wherein at least one of the inlet-side container element and the outlet-side container element is provided with a plurality of ribs including the rib, and
the ribs are configured to extend linearly and be arranged parallel to each other.

Assignees

• Asahi Kasei Medical Co Ltd

Inventors

• Matsuura Yoshimasa

Classifications

• A61M1/3635

  Constructional details · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title

• A61M2205/7545

  for solid matter, e.g. microaggregates · CPC title

• A61M1/0281 Primary

  Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing · CPC title

• A61M2202/0439

  White blood cells; Leucocytes · CPC title