Intravascular magnetic wire for detection, retrieval or elimination of disease-associated biomarkers and toxins

Patent metadata

Field	Value
Publication number	US-10064653-B2
Application number	US-201615175959-A
Country	US
Kind code	B2
Filing date	Jun 7, 2016
Priority date	Jun 8, 2015
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

A medical device and method for detection, retrieval or elimination of disease-associated toxins and biomarkers is provided. A plurality of magnets is arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached to each other, end-to-end, and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. The medical device is completely self-contained and does not require a bulky external field source able to maintain strong magnetic field gradients (100-10,000 T/m) along the wire, and at a radial distance (˜1 mm) to attract magnetic particles throughout the entire vein diameter at a range of physiologic velocities (1-10 cm/sec). This technology is a major step forward for the clinical relevance of CTC analysis to personalized medicine and introduces a powerful generalizable strategy for enrichment of other rare blood biomarkers.

First claim

What is claimed is:

1. A medical device for detection, retrieval or elimination of disease-associated toxins and biomarkers, comprising:
a plurality of magnets arranged within a flexible sheath forming a flexible wire, the flexible wire having a surface and a length axis,
wherein the magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction, each of the magnets having a magnetization direction;
wherein the magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire;
wherein the medical device is dimensioned to be introduced into a blood vessel, to be kept as a self-contained device within the blood vessel and to be retrieved from the blood vessel;
wherein the medical device is dimensioned to allow blood flow along the length axis while being kept within the blood vessel;
wherein a magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which could bind themselves to the disease-associated toxins and biomarkers;
wherein the magnets are displaceable from the sheath upon retrieving the medical device from the blood vessel for capturing and analysis of disease-causing cells, the biomarkers or the toxins; and
wherein the self-containing device operates without an external magnetic source.

2. The medical device as set forth in claim 1 , wherein the magnets are cylindrical magnets each having a diametric magnetization.

3. The medical device as set forth in claim 1 , wherein the magnets are cylindrical magnets having a diameter of 0.2 mm to 10 mm.

4. The medical device as set forth in claim 1 , wherein the alternating polarities alternate 180 degrees or alternate with a rotation from magnet to magnet at 45-180 degree increments.

5. The medical device as set forth in claim 1 , wherein each of the plurality of magnets has a length in a range of 0.5 mm to 10 cm.

6. The medical device as set forth in claim 1 , wherein the medical device contains 10 to 1000 magnets.

7. The medical device as set forth in claim 1 , wherein the flexible wire generates magnetic field gradients of 100 to 10,000 T/m.

8. The medical device as set forth in claim 1 , wherein the disease-associated toxins and biomarkers are cells, proteins, nucleic acids, circulating tumor DNA, or exosomes.

Assignees

• Univ Leland Stanford Junior

Inventors

• Vermesh Ophir
• Gambhir Sanjiv Sam
• Park Seung-Min
• Ge Tianjia Jessie
• Aalipour Amin

Classifications

• A61B5/05

  Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24) · CPC title

• A61N2/06

  using magnetic fields produced by permanent magnets (A61N2/12 takes precedence) · CPC title

• A61B5/6851

  Guide wires · CPC title

• A61B10/04 Primary

  Endoscopic instruments, e.g. catheter-type instruments · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title