Compact high volume analytical instrument architecture

Patent metadata

Field	Value
Publication number	US-10060938-B2
Application number	US-201415027683-A
Country	US
Kind code	B2
Filing date	Oct 15, 2014
Priority date	Oct 17, 2013
Publication date	Aug 28, 2018
Grant date	Aug 28, 2018

Abstract

An analytical instrument architecture provides high analytical test throughput in a compact footprint. A dilution section creates dilutions of a sample, a reaction processing section contains containers for assay reaction and measurement, and a reagent storage section supports reagent storage and supply. Transfer probes move the dilution and reagents to reaction containers. The dilution processing section includes concentric, independently driven rings of dilution containers; the reaction processing section includes concentric rings of reaction containers driven by the same mechanism for parallel processing of assays.

First claim

We claim:

1. An architecture for a compact high volume automated clinical analyzer, comprising:
an access position for access of samples;
a diluting turntable comprising a plurality of diluting containers arranged in a first diluting ring and a second diluting ring, the first diluting ring and the second diluting ring being concentric and independently-driven and controllable with respect to one another;
a diluting probe for transferring sample from the access position and creating a dilution in one or more of the plurality of diluting containers on either of the first diluting ring or the second diluting ring;
a reaction turntable comprising a plurality of reaction containers arranged in a first reaction ring and a second reaction ring, the first reaction ring and the second reaction ring being concentric and operating in parallel with respect to one another;
a plurality of sample transfer probes comprising a first sample transfer probe and a second sample transfer probe, the first sample transfer probe being dedicated to the first reaction ring for transferring the dilution from the one or more of the plurality of diluting containers on the first diluting ring to one or more of the plurality of reaction containers on the first reaction ring, the second sample transfer probe being dedicated to the second reaction ring for transferring the dilution from the one or more of the plurality of diluting containers on the second diluting ring to one or more of the plurality of reaction containers on the second reaction ring, the plurality of sample transfer probes independently-driven and controllable with respect to one another;
a reagent storage section comprising a plurality of reagent storage areas, each of the plurality of reagent storage areas dedicated to storage and supply of a respective reagent, each reagent storage area comprising a plurality of reagent containers arranged in a first reagent ring and a second reagent ring, the first reagent ring and the second reagent ring being concentric and independently-driven and controllable with respect to one another, wherein the first reagent ring is dedicated to the first reaction ring and the second reagent ring is dedicated to the second reaction ring;
a plurality of reagent transfer probes comprising a first reagent transfer probe and a second reagent transfer probe, the first reagent transfer probe dedicated to the first reagent ring for transferring a reagent from one or more of the plurality of reagent containers on the first reagent ring to one or more of the plurality of reaction containers on the first reaction ring, the second reagent transfer probe dedicated to the second reagent ring for transferring a reagent from one or more of the plurality of reagent containers on the second reagent ring to one or more of the plurality of reaction containers on the second reaction ring, the plurality of reagent transfer probes independently-driven and controllable with respect to one another; and
a controller for controlling operation of the diluting probe, the diluting turntable, the reaction turntable, the plurality of sample transfer probes, the reagent storage section, and the plurality of reagent transfer probes to provide parallel processing of assays through separate processing paths including a first processing path and a second processing path,
wherein the first diluting ring, the first sample transfer probe, the first reaction ring, the first reagent ring, and the first reagent transfer probe are elements of the first processing path and the controller controls operation such that the elements of the first processing path are dedicated to each other,
wherein the second diluting ring, the second sample transfer probe, the second reaction ring, the second reagent ring, and the second reagent transfer probe are elements of the second processing path and the controller controls operation such that the elements of the second processing path are dedicated to each other, and
wherein the reaction container is moved from the corresponding one of the plurality of reaction rings to another location for measurement by a detector.

2. The architecture of claim 1 , wherein the detector comprises a luminometer.

3. The architecture of claim 1 , wherein one of the plurality of diluting rings operates synchronously during a given cycle.

4. The architecture of claim 1 , wherein the plurality of diluting rings operate asynchronously at the same time.

5. The architecture of claim 1 , wherein, when one of the plurality of diluting rings returns to synchronous operation after running asynchronously, the one of the plurality of diluting rings resumes a synchronous cycle at a previous left-off position.

6. The architecture of claim 1 , wherein the transferring of the reagent and transferring of the dilution are done at fixed times with respect to one another.

7. The architecture of claim 1 , further comprising:
an ion-selective electrode (ISE) port;
an ISE access position for access of samples to the ISE port; and
an ISE diluting probe for transferring sample from the ISE access position and
creating a dilution in the ISE port.

8. The architecture of claim 7 , wherein the ISE port operates independently of the diluting probe, the diluting turntable, the reaction turntable, the plurality of sample transfer probes, the reagent storage section, and the plurality of reagent transfer probes.

9. The architecture of claim 7 , wherein the access position and the ISE access position comprise the same physical location, and wherein the diluting probe and the ISE diluting probe alternate turns for accessing the sample.

10. The architecture of claim 1 , wherein the first reagent ring and the second reagent ring are both dedicated to the same reagent.

11. An architecture for a compact high volume automated clinical analyzer, comprising:
an access position for access of samples;
a diluting turntable comprising a plurality of diluting containers arranged in a first diluting ring and a second diluting ring, the first diluting ring and the second diluting ring being concentric and independently-driven and controllable with respect to one another;
a diluting probe for transferring sample from the access position and creating a dilution in one or more of the plurality of diluting containers on either of the first diluting ring or the second diluting ring;
a reaction turntable comprising a plurality of reaction containers arranged in a first reaction ring and a second reaction ring, the first reaction ring and the second reaction ring being concentric and operating in parallel with respect to one another;
a plurality of sample transfer probes comprising a first sample transfer probe and a second sample transfer probe, the first sample transfer probe being dedicated to the first reaction ring for transferring the dilution from the one or more of the plurality of diluting containers on the first diluting ring to one or more of the plurality of reaction containers on the first reaction ring, the second sample transfer probe being dedicated to the second reaction ring for transferring the dilution from the one or more of the plurality of diluting containers on the second diluting ring to one or more of the plurality of reaction containers on the second reaction ring, the plurality of sample transfer probes independently-driven and controllable with respect to one another;
a reagent storage section comprising a plurality of reagent storage areas, each of the plurality of reagent storage areas dedicated to storage and supply of a respective reagent, each reagent storage area comprising a plurality of reagent containers arranged in a first reagent ring and a second reagent ring, the

Assignees

• Siemens Healthcare Diagnostics Inc
• Siemens Healthcare Diagnotics Inc

Inventors

• Evers Timothy P
• Ariff Gregory D
• Nuzzaci Edward A
• Farina Edward F

Classifications

• G01N2035/0458

  Multiple concentric rows of wells · CPC title

• G01N2035/0453

  Multiple carousels working in parallel · CPC title

• G01N2035/0448

  composed of interchangeable ring elements · CPC title

• G01N35/025 Primary

  having a carousel or turntable for reaction cells or cuvettes · CPC title

• G01N2035/0443

  for reagents · CPC title