Methods and apparatus to mitigate bubble formation in a liquid

Patent metadata

Field	Value
Publication number	US-10058866-B2
Application number	US-201313801451-A
Country	US
Kind code	B2
Filing date	Mar 13, 2013
Priority date	Mar 13, 2013
Publication date	Aug 28, 2018
Grant date	Aug 28, 2018

Abstract

Methods and apparatus to mitigate bubble formation in a liquid are disclosed. An example apparatus disclosed herein includes a bottom wall, a first baffle cantilevered from the bottom wall, and a second baffle cantilevered from the bottom wall. The first baffle is spaced apart from the second baffle, and the first baffle and the second baffle are positioned radially relative to an axis of rotation of the apparatus.

First claim

What is claimed is:

1. An apparatus, comprising:
a base;
a reagent container coupled to the base, the base configured to couple the reagent container to a rotatable carousel of a diagnostic analyzer, the reagent container to hold a liquid reagent to be used by the diagnostic analyzer for performing a diagnostic test on a sample, the reagent container comprising:
a first sidewall;
a second sidewall opposite the first sidewall;
a first end wall coupled between the first sidewall and the second sidewall;
a second end wall coupled between the first sidewall and the second sidewall opposite the first end wall;
a top wall coupled to and extending between the first sidewall, the second sidewall, the first end wall and the second end wall; and
a bottom wall opposite the top wall, the bottom wall coupled to the first sidewall, the second sidewall, the first end wall and the second end wall,
wherein the first sidewall, the second sidewall, the first end wall, the second end wall, the top wall and the bottom wall form a substantially enclosed volume,
wherein a first axis of the reagent container extends through the top wall and the bottom wall between the first sidewall and the second sidewall, and a second axis of the reagent container extends through the first sidewall and the second sidewall between the top wall and the bottom wall, the reagent container having a height along the first axis greater than a width along the second axis;

a first baffle extending from the bottom wall, the first baffle spaced apart from the first sidewall, the second sidewall, and the top wall such that the liquid reagent can flow between the first baffle and the first and second sidewalls; and
a second baffle extending from the bottom wall, the second baffle spaced apart from the first sidewall, the second sidewall and the top wall such that the liquid reagent can flow between the second baffle and the first and second sidewalls, the first and second baffles having c-shaped cross-sections, the first and second baffles spaced apart from each other and aligned along an axis extending between the first and second sidewalls.

2. The apparatus of claim 1 , wherein the first baffle has a first height and the second baffle has a second height greater than the first height.

3. The apparatus of claim 1 , wherein the top wall includes a first portion and a second portion, the first portion at a first height relative to the bottom wall and the second portion at a second height relative to the bottom wall greater than the first height, the first portion and the second portion connected by a non-vertical slope of the top wall.

4. The apparatus of claim 3 , wherein the second portion defines an enclosed crown forming a cavity extending upward from an underside of the top wall to enable the liquid reagent to flow into the cavity when the reagent container is rotated.

5. The apparatus of claim 3 , wherein the first baffle has a third height different than the first height and the second height.

6. The apparatus of claim 5 , wherein the third height is greater than the first height.

7. The apparatus of claim 5 , wherein the first baffle and the second baffle disposed radially relative to an axis of rotation of the apparatus.

8. The apparatus of claim 5 , wherein the second baffle has a fourth height different than the first height, the second height and the third height.

9. The apparatus of claim 8 , wherein the fourth height is less than the first height and the third height is greater than the first height.

10. The apparatus of claim 3 , wherein the liquid reagent is disposed below the first height when the apparatus is stationary, and wherein a portion of the liquid reagent is disposed between the first height and the second height during rotation of the apparatus.

11. The apparatus of claim 3 , wherein the first baffle extends a third height between the first height and the second height.

12. The apparatus of claim 3 , wherein the first portion is in a first horizontal plane and the second portion is in a second horizontal plane different than the first horizontal plane.

13. The apparatus of claim 1 , wherein the bottom wall is curved such that an end of the bottom wall is separated from the top wall by a first distance and a center of the bottom wall is separated from the top wall by a second distance, the second distance greater than the first distance.

14. The apparatus of claim 1 , wherein the first baffle is spaced apart from the first end wall and the second end wall such that liquid reagent can flow between the first baffle and the first and second end walls.

15. The apparatus of claim 1 , wherein a first distance between the first sidewall and the second sidewall adjacent the first end wall is less than a second distance between the first sidewall and the second sidewall adjacent the second end wall.

16. The apparatus of claim 15 , wherein the first baffle is disposed closer to the first end wall than the second baffle.

17. The apparatus of claim 16 , wherein the first baffle has a smaller cross-sectional size than the second baffle.

18. The apparatus of claim 15 , wherein the first sidewall and the second sidewall are nonparallel.

19. The apparatus of claim 1 , wherein a concave portion of the first baffle facing an axis of rotation of the reagent container.

20. The apparatus of claim 1 , wherein the first baffle extends a first distance from the bottom wall and the second baffle extends a second distance from the bottom wall, the second distance less than the first distance.

21. The apparatus of claim 1 , wherein the c-shaped cross-section of the second baffle has a larger radius than the c-shaped cross-section of the first baffle.

22. The apparatus of claim 1 , wherein the first and second baffles reduce bubble formation in the liquid reagent as the liquid reagent moves in the reagent container.

23. The apparatus of claim 1 , wherein the top wall includes an upward extending throat.

24. The apparatus of claim 23 , further including a cap that is removably coupled to the throat.

25. The apparatus of claim 1 , wherein the reagent container is a first reagent container, the bottom wall is a first bottom wall, and the top wall is a first top wall, further including:
a second reagent container coupled to the base adjacent the first reagent container, the second reagent container including a third baffle and a fourth baffle extending from a second bottom wall of the second reagent container, the third baffle and the fourth baffle spaced apart from a third sidewall, a fourth sidewall and a second top wall of the second reagent container such that a liquid can flow between the third and fourth baffles and the third and fourth sidewalls, the third and fourth baffles having c-shaped cross-sections, the third and fourth baffles spaced apart from each other and aligned along an axis extending between the third and second sidewalls.

26. The apparatus of claim 1 , wherein the top wall includes an exterior surface having a first portion and a second portion, the first portion at a first height relative to the bottom wall and the second portion at a second height relative to the bottom wall greater than the first height.

27. A system comprising:
a reagent container including:
a first sidewall;
a second sidewall opposite the first sidewall;
a first end wall coupled between the first sidewall and the second sidewall

Assignees

• Luoma Ii Robert Paul
• Ochranek Brian
• Davidson Cheryl L
• Weston Bradley
• Abbott Lab

Inventors

• Luoma Ii Robert Paul
• Ochranek Brian
• Davidson Cheryl L
• Weston Bradley

Classifications

• G01N35/1002

  Reagent dispensers · CPC title

• B01L2300/0851

  Bottom walls · CPC title

• G01N2035/1025

  Fluid level sensing · CPC title

• G01N2035/0439

  Rotary sample carriers, i.e. carousels · CPC title

• B01L2400/086

  using baffles or other fixed flow obstructions · CPC title