Alkyl cellulose for use in tableting and solid preparation comprising same

Patent metadata

Field	Value
Publication number	US-10058509-B2
Application number	US-201715622354-A
Country	US
Kind code	B2
Filing date	Jun 14, 2017
Priority date	Oct 23, 2014
Publication date	Aug 28, 2018
Grant date	Aug 28, 2018

Abstract

Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m 2 /g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.

First claim

The invention claimed is:

1. An alkyl cellulose for use in tableting, wherein the alkyl cellulose has a specific surface area of from 0.5 to 10.0 m 2 /g as measured by BET method.

2. The alkyl cellulose for use in tableting according to claim 1 , wherein an aqueous solution comprising 2% by weight of said alkyl cellulose has a viscosity at 20° C. of from 1 to 15 mPa·s.

3. The alkyl cellulose for use in tableting according to claim 1 , the alkyl cellulose having an average particle size of from 1 to 120 μm.

4. The alkyl cellulose for use in tableting according to claim 1 , the alkyl cellulose having a loose bulk density of from 0.01 to 0.50 g/mL.

5. The alkyl cellulose for use in tableting according to claim 1 , the alkyl cellulose being methyl cellulose.

6. A solid preparation comprising the alkyl cellulose for use in tableting according to claim 1 .

7. The alkyl cellulose for use in tableting according to claim 1 , wherein the specific surface area is from 1.2 to 2.0 m 2 /g as measured by BET method.

8. The alkyl cellulose for use in tableting according to claim 2 , wherein the viscosity at 20° C. is from 2.5 to 4.5 mPa·s.

9. The alkyl cellulose for use in tableting according to claim 3 , wherein the average particle size is from 10 to 30 μm.

10. The alkyl cellulose for use in tableting according to claim 3 , wherein the loose bulk density is from 0.2 to 0.4 g/mL.

Assignees

• Shinetsu Chemical Co

Inventors

• Yokosawa Takuya
• Maruyama Naosuke

Classifications

• C08B11/20

  Post-etherification treatments of chemical or physical type, {e.g. mixed etherification in two steps}, including purification · CPC title

• A61K9/2095

  Tabletting processes · CPC title

• A61K9/2054 Primary

  Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title

• C08B11/02

  Alkyl or cycloalkyl ethers · CPC title

• A61K31/167

  having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol · CPC title