Easily formulated zinc oxide powder

Patent metadata

Field	Value
Publication number	US-10058489-B2
Application number	US-201715432581-A
Country	US
Kind code	B2
Filing date	Feb 14, 2017
Priority date	May 15, 2012
Publication date	Aug 28, 2018
Grant date	Aug 28, 2018

Abstract

The present disclosure relates to zinc oxide particles having a mean particle size (volume) distribution of about 400 nm to about 650 nm, where the zinc oxide particles are formed by gas phase plasma deposition without milling and remain discrete particles after formation. The present disclosure further relates to the use of the zinc oxide particles in a dispersion. The present disclosure further relates to the use of the zinc oxide particles in a sunscreen composition. The present disclosure further relates to a method of formulating the sunscreen composition.

First claim

The invention claimed is:

1. A sunscreen composition comprising a) zinc oxide particles having a mean volume particle size distribution of about 400 nm to about 650 nm measured by Dynamic Light Scattering, and a hexagonal zincite crystal structure; wherein 0.0% of the zinc oxide particles by number have a particle size below 100 nm; and b) an organic ultra-violet (UV) screen agent of formula (2a), (2b), (3a) or 3(b); wherein a weight ratio of the zinc oxide to the organic UV screen agent is from about 25:1 to about 1:1;

wherein: R 6 and R 7 independently of one another, are C3-C18 alkyl or —CH 2 —CH(—OH)—CH 2 —O—T 1 ; R 8 is C1-C10 alkyl or a radical of formula (2a 1 )

 or formula (2a 2 )

the mark * is a single bond;
R 9 is hydrogen, M, C 1 -C 5 alkyl, or a radical of formula —(CH 2 ) m —O—T 2 ;
M is a metal cation;
T 1 and T 2 independently of one another are hydrogen or C 1 -C 5 alkyl; and m is 1to 4.

2. The sunscreen composition of claim 1 , wherein the zinc oxide particles have a mean volume particle size distribution of about 475 nm to about 600 nm.

3. The sunscreen composition of claim 1 , wherein the zinc oxide particles have an average crystal size of about 200 nm to about 300 nm.

4. The sunscreen composition of claim 1 , wherein the zinc oxide particles are present in an amount of about 1 to about 15 wt. % of the sunscreen composition.

5. The sunscreen composition of claim 1 , wherein the zinc oxide particles are coated with a hydrophobic coating to form coated zinc oxide particles, wherein the hydrophobic coating on the zinc oxide particles is present in an amount from 0.01 to about 5 wt. % based on a total weight of the coated zinc oxide particles.

6. The sunscreen composition of claim 1 , wherein the sunscreen composition is provided in a form of a cream, a gel, a lotion, an emulsion, stick preparations, powders, or ointments.

7. A dispersion comprising: zinc oxide particles having a mean volume particle size distribution of about 400 nm to about 650 nm measured by Dynamic Light Scattering, and a hexagonal zincite crystal structure; wherein 0.0% of the zinc oxide particles by number have a particle size below 100 nm; and a carrier comprising a hydrophobic liquid suitable for skin contact, wherein the carrier comprises an organic ultra-violet (UV) screen agent of formula (2a), (2b), (3a) or(3b); wherein a weight ratio of the zinc oxide to the organic UV screen agent is from about 25:1 to about 1:1;

Wherein: R 6 and R 7 independently of one another, are C3-C18 alkyl or —CH 2 —CH(—OH)—CH 2 —O—T 1 ; R 8 is C1-C10 alklyl or a radical of formula(2a 1 )

 or formula (2a 2 )

The mark * is a single bond; R 9 is hydrogen, M, C 1 -C 5 alkyl, or a radical of formula —(CH 2 ) m —O—T 2 ; M is a metal cation; T 1 and T 2 independently of one another are hydrogen or C 1 -C 5 alkyl; and m is 1 to 4.

8. The dispersion of claim 7 , wherein the carrier is selected from a group comprising C 6 -C 18 fatty acids esters of di- or tri-glycerides, fatty acids esters of polyglycerol, hydrogenated vegetable oil, sweet almond oil, wheat germ oil, sesame oil, hydrogenated cottonseed oil, coconut oil, corn oil, hydrogenated castor oil, shea butter, cocoa butter, soybean oil, mink oil, sunflower oil, safflower oil, macadamia nut oil, olive oil, hydrogenated tallow, apricot kernel oil, hazelnut oil, and borage oil, wherein the zinc oxide particles are present in an amount of at least about 50 to about 90 weight percent by total weight of the dispersion.

9. The dispersion of claim 7 , wherein the carrier comprises an organic ultra-violet screen agent of formula (1)

wherein:
combination of the compound of formula (1) with zinc oxide particles increases ultra-violet (UV) absorbance in UV-A region; and
weight ratio of zinc oxide particles to the compound of formula (1) is from about 20:1 to 5:1 in the dispersion.

10. A method of formulating a sunscreen composition, the method comprising: adding zinc oxide particles to a carrier, wherein the zinc oxide particles have a mean volume particle size distribution of about 400 nm to about 650 nm measured by Dynamic Light Scattering and a hexagonal zincite crystal structure; wherein 0.0% of the zinc oxide particles by number have a particle size below 100 nm, wherein the carrier is a hydrophobic liquid suitable for skin contact and wherein the carrier comprises an organic ultra-violet (UV) screen agent of formula (2a), (2b), (3a) or (3b); wherein a weight ratio of the zinc oxide to the organic UV screen agent is from about 25:1 to about 1:1;

wherein: R 6 and R 7 independently of one another, are C3-C18 alkyl or —CH 2 —CH(—OH)—CH 2 —O—T 1 ; R 8 is C1-C10 alkyl or a radical of formula(2a 1 )

 or formula (2a 2 )

The mark * is a single bond; R 9 is hydrogen, M, C 1 -C 5 alkyl; or a radical of formula —(CH 2 ) m —O—T 2 ; M is a metal cation; T 1 and T 2 independently of one another are hydrogen or C 1 -C 5 alkyl; and m is 1 to 4.

11. The method of claim 10 , wherein the zinc oxide particles are formed by gas phase nucleation of vaporized zinc metal.

12. The method of claim 10 , wherein: the zinc metal is vaporized by being fed into a plasma arc to form vaporized zinc metal; oxygen is added to the vaporized zinc metal to produce zinc oxide; the zinc oxide is condensed by cooling to form the zinc oxide particles; and the zinc oxide particles are nanocrystalline.

13. The method of claim 12 , wherein the zinc oxide particles are formed without any other reactions, by-products, or waste streams.

14. The method of claim 10 , wherein the zinc oxide particles are surface treated with an organosilicon compound comprising at least one of silicone or polysiloxane to render the zinc oxide particles hydrophobic.

15. The method of claim 14 , wherein a side group of the organosilicon compound matches the carrier to provide affinity between the zinc oxide particles and the carrier.

16. The method of claim 10 , wherein the zinc oxide particles are treated with monomers or oligomers that polymerize in presence of the zinc oxide particles.

17. The method of claim 10 , wherein the zinc oxide particles are reacted with a triethoxyoctyl silane monomer, wherein the triethoxyoctyl silane monomer reacts with itself on and around surface of the zinc oxide particles and forms zinc oxide particles coated with poly-n-octylsilsesquioxane, wherein dispersion of the zinc oxide particles before coating and after coating have substantially same transparency.

Assignees

• Basf Se

Inventors

• Drovetskaya Tatiana
• De Mul Marc N G

Classifications

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• A61Q17/04

  Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations · CPC title

• A61K2800/624

  by macromolecular compounds · CPC title

• A61K2800/412

  Microsized, i.e. having sizes between 0.1 and 100 microns · CPC title

• A61K8/891

  saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone · CPC title